buprenorphine is a partial mu agonist and kappa antagonist which is used for the treatment of pain and opioid addiction. a mixture of buprenorphine hydrochloride and naloxone hydrochloride has been approved for the treatment of opioid dependence.in this study a third order derivative spectrophotometric method based on zero-crossing technique has been used for the simultaneous determination of b...

We report a unique anomaly in the ocular dominance column pattern of a single, normally pigmented macaque monkey. The column pattern contained large monocular areas inserted between the normal columns and the dorsal V1 border. These monocular regions received transneuronal input from the contralateral eye, indicating that a small population of temporal ganglion cells erroneously decussated at t...

This paper proposes an extension of edge detectors based on second-order differential operators to the case of multiple band (color) images. To this end, we deline a local directional measure of multispectral contrast. A definition of edge point is then given, as the location of a directional maximum of the contrast function. Extremal contrast edges are defined, as loci of zero crossing points ...

A pseudo-wavefunction description of time-dependent Hartree-Fock (TDHF) states is proposed and used to develop an analytic expression for derivative couplings between TDHF excited states based on the Hellmann-Feynman theorem. The resulting expression includes Pulay terms associated with using an atom-centered basis as well as a correction to ensure translational invariance. We demonstrate that ...

Anthropogenic climate change profoundly alters the ocean’s environmental conditions, which, in turn, impact marine ecosystems. Some of these changes are happening fast and may be difficult to reverse. The identification monitoring such changes, which also includes tipping points, is an ongoing emerging research effort. Prevention negative impacts requires mitigation efforts based on feasible re...