In a guinea pig model of allergic asthma, we investigated the effects of the selective phosphodiesterase inhibitors rolipram (phosphodiesterase 4-selective), Org 9935 (phosphodiesterase 3-selective) and Org 20241 (dual phosphodiesterase 4/phosphodiesterase 3-selective), administered by aerosol inhalation in approximately equipotent bronchodilatory doses, on allergen-induced early and late asthm...

Some actions of Org NC 45 have been compared with those of pancuronium in a study on 50 patients anesthetized with nitrous oxide and narcotic supplements. The train-of-four technique was used to assess the recovery of neuromuscular blockade and its antagonism. Org NC 45 was shown to have a duration of action from injection of the intubating dose (0.1 mg kg-1) to the reappearance of the first tw...

BACKGROUND Acetylcholinesterase inhibitors are widely used for the reversal of neuromuscular blocking agents. However, acetylcholinesterase inhibitors have several side effects and are not effective during profound block. Org 25969 is a modified gamma-cyclodextrin that encapsulates the neuromuscular blocking agent, rocuronium bromide (Esmeron/Zemuron, NV Organon, Oss, The Netherlands), forming ...

Title: A RESEARCH UTILIZATION FRAMEWORK FOR INFORMING GLOBAL HEALTH AND DEVELOPMENT POLICIES AND PROGRAMS Authors: Christine Kim ([email protected]) Rose Wilcher ([email protected]) Tricia Petruney ([email protected]) Kirsten Krueger ([email protected]) Leigh Wynne ([email protected]) Trinity Zan ([email protected]) Version: 1 Date: 16 Mar 2017 Author’s response to reviews: From the le...

Differences in adoption of selected practices used in welfare assessment and audit programs were contrasted among organic (ORG; n=192) herds and similarly sized conventional grazing herds (CON-GR; n=36), and conventional nongrazing herds (CON-NG; n=64). Criteria from 3 programs were assessed: American Humane Association Animal Welfare Standards for Dairy Cattle, Farmers Assuring Responsible Man...

[1] Laboratory experiments investigated the relationship between oxidation level and hygroscopic properties of secondary organic aerosol (SOA) particles generated via OH radical oxidation in an aerosol flow reactor. The hygroscopic growth factor at 90% RH (HGF90%), the CCN activity ( ORG,CCN) and the level of oxidation (atomic O:C ratio) of the SOA particles were measured. Both HGF90% and ORG,C...

The relative potency, time-course of action and cardiovascular effects of Org NC 45, a new non-depolarizing neuromuscular blocking agent, have been compared with those of pancuronium, alcuronium and tubocurarine in 64 anaesthetized patients. The relative potency (ED50) to Org NC 45 was 1.74, 3.69 and 8.57 respectively. In doses which caused useful surgical relaxation, duration of action of Org ...

The objective of the present investigation was to assess the possible involvement of GABAergic mechanism in analgesic effect of aqueous extract of Origanum Vulgare (ORG) in a rat model of acute pain test. Sixty-three anaesthetized male Wistar rats (200-250 g) were cannulated into the left ventricle. Five to seven days after the recovery from surgery, ORG extract was intraventricularly injected ...

The antagonism, by neostigmine, of neuromuscular blockade produced by either Org NC 45 or pancuronium was studied in 29 anaesthetized patients during a continuous infusion of the myoneural blocker. The ED50 of neostigmine (dose which produced a 50% antagonism) when antagonizing Org NC 45 and pancuronium was 0.011 mg kg-1 and 0.010 mg kg-1 respectively. The dose-response relationships for the an...