The gut microbiome and daily feeding/fasting cycle influence host metabolism and contribute to obesity and metabolic diseases. However, fundamental characteristics of this relationship between the feeding/fasting cycle and the gut microbiome are unknown. Our studies show that the gut microbiome is highly dynamic, exhibiting daily cyclical fluctuations in composition. Diet-induced obesity dampen...

IN A TYPICAL workweek, one in every four manufacturing production workers in the United States is employed at night. This fraction fluctuates sharply over the business cycle, accounting disproportionately for business cycle changes in employment. The variation in work at night amounts to over 40 percent of the cyclical changes in the employment of manufacturing production workers. While cyclica...

According to the firm life cycle theory, companies go through certain behavioral patterns in various stages of their life. A thorough understanding and recognition of these behavioral patterns, new investment in assets and the optimal use of assets can considerably enhance the capital productivity. In the current study, the relationship between the stages of firm life cycle and capital producti...

The polyamines, putrescine, spermidine, and spermine, undergo dramatic cyclical variation in both synthesis and accumulation during the early cleavage stages of sea-urchin development. Ornithine decarboxylase activity (putrescine synthesis) in developing Strongylocentrotus purpuratus exhibits maxima at •£• and 2 h after fertilization; increases in ornithine decarboxylase activity appear to corr...

Bronchoconstrictor responses are quantitatively different when they are evoked under static conditions and during or after periods of deep inspiration. In vivo, deep inspirations produce bronchodilation and protect the lung from subsequent bronchoconstriction (termed bronchoprotection). These effects may be due in part to dynamic stretch on airways produced by cyclical expansion of airway diame...

Atrial fibrillation (AF) often occurs in the presence of an underlying disease. These underlying diseases cause atrial remodelling, which make the atria more susceptible to AF. Stretch is an important mediator in the remodelling process. The aim of this study was to develop an atrial cell culture model mimicking remodelling due to atrial pressure overload. Neonatal rat atrial cardiomyocytes (NR...