The physiological disposition of l-(2-chloroethyl)-3cyclohexyl-1-nitrosourea, a highly active agent against intraperitoneal and intracranial mouse leukemia L1210, was studied in mice, rats, dogs, and monkeys with the 14C label in each of 3 positions of the molecule, the ethylene, carbonyl, and cyclohexyl moieties. l-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea is lipid soluble and, after parenter...

Abbreviations: CAPS: N-cyclohexyl-3-aminopropanesulfonic acid cDNA: omplementary DNA to mRNA CHES: N-cyclohexyl-2-aminoethanesulfonic acid. DTT: dithiothreitol FPLC: fast protein liquid chromatography IPTG: isopropylthio-β-D-galactoside LB: Luria-Bertani MES: 2-(N-morpholino)ethanesulfonic acid Ni-NTA: Nickel-nitriloacetic acid ORF: open reading frame PCR: polymerase chain reaction PMSF: phenyl...

Two routes to the synthesis of a cyclohexyl-fused 1,4,7-triazacyclononane involving macrocyclisations of tosamides have been investigated. In the first approach, using a classic Richman-Atkins-type cyclisation of a cyclohexyl-substituted 1,4,7-tritosamide with ethylene glycol ditosylate, afforded the cyclohexyl-fused 1,4,7-triazacyclononane in 5.86% overall yield in four steps. The second, more...

GENERAL METHODS S4 SYNTHESIS OF SUBSTRATES S4-S6 Synthesis of (Z)and (E)-1-cyclohexyl-1,3-butadiene (8) Typical procedure for the synthesis of (Z)and (E)-1,3-dienes (Z)and (E)-1-Benzylbuta-1,3-diene (18) (Z)and (E)-1-(2-Furyl)-1,3-butadiene (21) (Z)and (E)-1-(4-Butyl-1-cyclohexyl)-1,3-butadiene (22) SYNTHESIS OF COBALT COMPLEXES S7 CHEMOSELECTIVE ASYMMETRIC HYDROVINYLATIONS S7 Asymmetric hydrov...

A formulation of 1-[2-chloroethyl-U-14C]-3-cyclohexyl-1-nitrosourea in ethanol:propylene glycol (1:4, v/v) was administered to rats previously infiltrated with RT6 glioma tumors (astrocytic series); the organ and tumor tissue distribution was followed at 1, 4, 12, and 24 hr postinjection. From 0 to 1 hr, rapid blood disappearance of the 1-[2-chloroethyl-U-14C]-3-cyclohexyl-1-nitrosourea was obs...

Background and Objective: Regarding the prevalence of epilepsy in human society and with respect to insufficiency of usual treatments, new strategies and methods for medical treatment of epileptic patients are necessary. As NMDA receptor antagonists are the most prominent anti-epileptic drugs, in the present study, we synthesized and investigated anti-epileptic effect of a new piperidine deriva...

This paper investigates the effects of substituents in PNP-type ruthenium complexes catalytic hydrogenation CO2 to formate using DFT method. Six groups were considered as linked P atom PNP ligand: hydrogen, methyl, iso-propyl, tert-butyl, cyclopentyl, and cyclohexyl. The substituent analyzed from perspectives steric hindrance promotion hydrogen bonding. With joint functions bonding during coord...