Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects. In human lung cancer, fibroblast growth factor 9 (FGF9), a high-affinity ligand for FGFR3, is overexpressed in 10% of primary resected non-small cell lung cancer (NSCLC) specimens. Furthermore, in a mouse model where FGF9 can be induced in l...

The laser-induced fluorescence (LIF) excitation spectra of the 4-methylcyclohexoxy and d11-cyclohexoxy radicals have been measured for the first time. LIF intensity was used as a probe in direct kinetic studies of the reaction of O(2) with trans-4-methylcyclohexoxy and d11-cyclohexoxy radicals from 228 to 301 K. Measured rate constants near room temperature are uniformly higher than the Arrheni...

In this study, effect of acupuncture (AP) on the luteal size (LS), luteal blood flow (LBF) and progesterone (P4) levels were investigated in the presence of corpus luteum (CL) in cows. Seven days after 14-days interval PGF2α estrus synchronization protocol, CL positive animals were assigned either to a control group (AP–, n=10) or to an AP group (AP+, n=10) stimulated by using B22 and B23 sensi...

Streptococcus pneumoniae is an important cause of community-acquired pneumonia, meningitis, and bacteremia. The problem of pneumococcal disease is exacerbated by increasing drug resistance. Furthermore, patients with impaired immunity are at high risk for invasive pneumococcal infections. Thus, there is an urgent need for new approaches to antimicrobial therapy. Antibody therapies take advantag...

Antigenic diversity among the bovine viral diarrhea virus (BVDV) cytopathic strains 87-2552 (field isolate) and NADL and Singer (prototype strains) was demonstrated with monoclonal antibodies (MAbs) in enzyme-linked immunosorbent, immunofluorescence, virus neutralization, and immunoprecipitation assays. Two MAbs against BVDV strain 87-2552, designated D11 and B7, strongly neutralized this field...

PURPOSE To develop an experimental model of acute inflammation, like aphthous ulcers, in oral cavity of rabbits, and also, to evaluate the results of the application of a polysaccharide spongy film of molasses from sugar cane as assist treatment in the healing process. METHODS Twenty adult rabbits weighting between 2.5 kg and 3.9 kg were divided into two groups: experimental and control infec...

Spinal chondroma is a rare benign tumor it accounts for 2.8% of bone tumours and 12% all tumours. 3.6% to 4% are located in the spine representing 10% chondromas. It can originate from vertebral bodies or posterior arch described patients between 5 78 years age [1]. We present clinical case 60 year old woman, who consulted dorso-thoracic pain around belt line was treated as gastroduodenal ulcer...

Primitive neuroectodermal tumours (PNET) are aggressive childhood malignancies and offer a significant challenge to treatment. A two years old female child presented with weakness both lower limbs. Preoperative MRI of the spine and paravertebral regionIso - hyper intense posterior placed extradural lesion, non contrast enhancing from D11-L2 levels with cord compression D9 to L3 laminectomy done...