As a novel heat shock protein 90 inhibitor, AT-533 exhibits various biological activities in vitro, including anti-viral, anti-tumor and anti-inflammatory activities. Moreover, gel, gel dosage form of AT-533, has been suggested to have anti-keratitis herpes simplex virus type-1 infection-induced effects on the skin lesions animals. However, safety evaluation has, best our knowledge, not examine...

materials and methods: young adult sprague-dawley rats (200-250g) were assigned into one of the three different groups of control, sci, and adenovirus transfer (ad) (n=3/ group). control rats received no injury, nor any surgery. for sci rats, sci was produced by a 10g brass rod with a tip diameter of 2 mm which was dropped from a height of 12.5 mm onto exposed spinal cord at level of t10 with n...

The effect of high salt intake on rascular and renomedullary prostaglandin (PG) synthesis was compared in Sprague-Dawley and salt-sensitive (S) and -resistant (R) Dahl rats. Animals were given a diet containing either 0.6% or 8% NaCI starting at 5 weeks of age, and were sacrificed 6 weeks later. Systolic blood pressure of S rats increased to 220 ± 7 mm Hg but was unaffected in R and Sprague-Daw...

The effect of high salt intake on vascular and renomedullary prostaglandin (PG) synthesis was compared in Sprague-Dawley and salt-sensitive (S) and -resistant (R) Dahl rats. Animals were given a diet containing either 0.6% or 8% NaCl starting at 5 weeks of age, and were sacrificed 6 weeks later. Systolic blood pressure of S rats increased to 220 +/- 7 mm Hg but was unaffected in R and Sprague-D...

Background : Immunotherapy is widely used to increase the response rate of chemotherapy drugs. Eleuhterine palmifolia (L) Merr or dayak onion are known contain phytochemical compounds that have antiproliferative effects, and been as anti-cancer empirical therapies. This study aimed prove effect extract in Sprague-Dawley rats with breast cancer.
 Methods 18 Sprague-dawley rats, divided into...

according to iran’s folk medicine, camphor, a crystalline ketone obtained from essential oils of cinnamomum camphora, has both sexual behavior attenuating and enhancing properties. this study examined the effects of camphor on sexual behavior in male rats. twenty four sexually mature male sprague-dawley rats were randomly divided into 4 groups receiving daily i.p. injections of olive oil as veh...

In the study of tissues that contain several forms of one cytochrome P450 subfamily, it is useful to develop immunoblotting techniques so that the various individual members of the family can be distinguished. This paper describes improvements in the immunoblotting technique to distinguish members of the rat cytochrome P450 4A subfamily, 4A1, 4A2, and 4A3, as they are present in Sprague-Dawley ...

The aim of this study was to determine the range and incidences of spontaneous microscopic lesions of the pituitary gland in control Han-Wistar and Sprague-Dawley rats and CD-1 mice from 104-week carcinogenicity studies carried out between 1998 and 2010 at Charles River Edinburgh. In both strains of rats and in CD-1 mice, non-proliferative lesions of the pituitary gland were generally uncommon,...