Delayed puberty is a frequent complication of inflammatory bowel disease. The precise etiological mechanisms are not known. In this study, we wanted to determine the relative contribution of undernutrition and inflammation to delayed puberty and the effect of inflammation on the reproductive axis. Puberty was assessed in rats with 2,4,6-trinitrobenzenesulfonic acid induced-colitis, healthy cont...

The timing of puberty is a critical life history trait of short-lived species; spring-born individuals mature rapidly and breed in the season of birth, whereas young born in mid- to late summer delay puberty until the next spring. The cues that govern the transition from rapid to delayed maturation in natural populations remain unknown. To identify ecologically relevant photoperiod cues that co...

background: precocious puberty, as early physical development and low final height might lead to psychosocial problems. objective: to evaluate etiology and clinical feature of precocious puberty in a cohort of iranian children. materials and methods: in this case-series study, 44 girls and 8 boys with precocious puberty referred to endocrine reserch centre (firouzgar), institute of endocrinolog...

There are many indications for exogenous Testosterone (T) use in adolescents. Induction of puberty in males with Constitutional Delay of Growth and Puberty (CDGP) and replacement therapy for adolescents with hypogonadism constitutes the most common indications. In this mini-review the authors go through the physiologic role of androgen, pathological conditions that require its use and review so...

INTRODUCTION Malnutrition, delayed growth and delayed puberty are commonly seen in children with cystic fibrosis. The aim of this study was to evaluate growth, nutritional status and body proportions in children and adolescents suffering from cystic fibrosis. MATERIAL AND METHODS The evaluation was based on 19 somatic measurements and indices calculated from these measurements. Somatic develo...

Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis manifests as gonadotropin-dependent precocious puberty. The mechanisms behind HPG activation are complex and a clear etiology for early activation is often not elucidated. Though collectively uncommon, the neoplastic and developmental causes of gonadotropin-dependent precocious puberty are very important to consider, as a del...

INTRODUCTION Ballet dancers (BDs) have a negative energy balance related to physical training that results in alterations in body composition, sexual development, and adipokine secretion. Our aims were to study anthropometric parameters, body composition, and their relationship with adipokines throughout pubertal development. SUBJECTS AND METHODS We carried out a prospective follow-up study o...

This study was to investigate the effect of soyabean isoflavones (SIF) on onset of puberty, serum hormone concentration, and gene expression in hypothalamus, pituitary and ovary of female Bama miniature pigs. Fifty five, 35-days old pigs were randomly assigned into 5 treatment groups consisting of 11 pigs per treatment. Results showed that dietary supplementation of varying dosage (0, 250, 500,...

SUMMARY Corticotroph adenomas are extremely rare in children and adolescents. We present a 15-year-old boy who was investigated for delayed puberty (A1P2G1, bilateral testicular volumes of 3 mL each). There was no clinical or laboratory evidence suggestive of chronic illness, and the initial clinical impression was constitutional delay in puberty. Subsequently, MRI scan of the brain revealed th...