PURPOSE Milk thistle (Silybum marianum) is one of the most commonly used herbal therapies, and its principal constituent silybin significantly inhibits cytochrome P450 isoform 3A4 (CYP3A4) and UDP glucuronosyltransferase isoform 1A1 (UGT1A1) in vitro. Here, we investigated whether milk thistle affects the pharmacokinetics of irinotecan, a substrate for CYP3A4 and UGT1A1, in humans. EXPERIMENT...

Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymar...

In this study, the effect of vermicompost and mycorrhizal fungi was investigated on growth, yield, chlorophyll pigments, leaf antioxidant enzymes, and seed silibinin content of Silybum marianum, milk thistle. The seeds were inoculated by two species of mycorrhiza fungi, Glomus mosseae and G. intraradices, and plants were irrigated and treated with 0, 25, 50, and 75% vermicompost after culturing...

in order to evaluate the effects of organic, biological and chemical fertilizers on yield and yield components of milk thistle (silybum marianum l.), an experiment was conducted at the research station of ferdowsi university of mashhad based on complete randomized block design with three replications and six treatments during year 2007. treatments included inoculated seeds with azotobacter, com...

BACKGROUND Silybum marianum L. (Milk thistle) is native to the Mediterranean basin and is now widespread throughout the world. It's sprout is used as a herbal medicine for the treatment of liver disease for centuries. The seeds of milk thistle contain silymarin, an isomeric mixture of flavonolignans [silybin, silychristin, and silydianin]. Silymarin acts as a strong anti-hepatotoxic. OBJECTIV...

Phytochemical-mediated modulation of P-glycoprotein (P-gp) and other drug transporters may underlie many herb-drug interactions. Serial serum concentration-time profiles of the P-gp substrate, digoxin, were used to determine whether supplementation with milk thistle or black cohosh modified P-gp activity in vivo. Sixteen healthy volunteers were randomly assigned to receive a standardized milk t...

Milk thistle is a medicinal plant with anti-inflammatory, antioxidant properties and in the treatment of chronic liver diseases. The therapeutic this have been showed within Alzheimer’s malady, Parkinson’s illness, burns, osteoporosis, cholestasis, sepsis, hypercholesterolemia, diabetes. can be used to decrease side effects chemotherapy radiation therapy for various types cancer.

One hundred forty four 10-day old male Arbor Acres (320±5g) broiler chicks were used to compare the responses in liver function to dietary supplementation of milk thistle (Silybum marianum), artichoke (Cichorium intybus) and olive (Olea europaea) extracts with gemfibrozil and atorvastatin, in broiler chickens fed with a lipogenic diet. Birds raised in the standard experimental conditions and re...