Merkel cell carcinoma is a malignant skin tumor with a poor prognosis that primarily affects photoexposed areas of elderly patients. Tumor size is a very strong prognostic factor, with much better outcomes associated with small lesions, measuring less than 1cm. However, such lesions are rarely seen in the clinic in view of the rapid growth of this tumor. We report 2 cases of incipient Merkel ce...

Delivering a drug into and through the skin is of interest as the skin can act as an alternative drug administration route for oral delivery. The development of new delivery methods, such as microneedles, makes it possible to not only deliver small molecules into the skin, which are able to pass the outer layer of the skin in therapeutic amounts, but also macromolecules. To provide insight into...

Introduction: Skin resistance is greatly dependent on its collagen amount and nutritional substances such as crude protein that affect the skin collagen can indirectly influence the skin resistance and increase its strength. In this regard, this study aimed to evaluate the effect of in ovo methionine injection on histomorphometry of the skin layers. Methods: Thirty fertilized eg...

background: microcystic adnexal tumor is a rare sclerosing variant of ductal carcinoma of eccrine sweat glands which is highly invasive. this tumor is often misdiagnosed as other benign or malignant skin lesions and improper treatment is carried on and is associated with high recurrence rate. case presentation: we reported here in a 59-years old man who underwent incisional biopsy for a ongenit...

BACKGROUND/AIMS Human skin is a complex tissue consisting of several distinct layers. Each layer consists of various components with a specific structure. To gain a better insight into the overall mechanical behaviour of the skin, we wish to study the mechanical properties of the different layers. A numerical-experimental method was developed to characterize the non-linear mechanical behaviour ...

introduction: skin resistance is greatly dependent on its collagen amount and nutritional substances such as crude protein that affect the skin collagen can indirectly influence the skin resistance and increase its strength. in this regard, this study aimed to evaluate the effect of in ovo methionine injection on histomorphometry of the skin layers. methods: thirty fertilized eggs of ross 308 b...

Ultrasound imaging of the skin is becoming more and more popular. Skin ultrasound examinations are used both in order to assess healthy skin and to evaluate pathological lesions. They are mainly performed in dermatology as well as in broadly understood aesthetic medicine and cosmetology. At present, skin imaging is enabled by high-frequency equipment and high-quality conventional devices. The i...

Hyaluronan has recently been introduced as a vehicle for topical application of drugs to the skin. We sought to determine whether hyaluronan acts solely as a hydrophilic reservoir on the surface of intact skin or might partly penetrate it. Drug-free hyaluronan gels were applied to the intact skin of hairless mice and human forearm in situ, with and without [3H] hyaluronan. [3H]hyaluronan was sh...

The cytotoxic effects of excessive zinc is well documented but its effect on cytodifferentiation appears relatively unknown. We show here that chronic administration (25 days) of zinc chloride in C57/6J mice (11 to 56 micrograms/g body weight, 5 times per week), which was lower than the in vitro cytotoxic level, caused a loss of long coarse hairs, which were replaced by short fine (vello) hairs...