BACKGROUND Desmoid tumors that present as a part of Gardener's syndrome can present very difficult management problems. CASE PRESENTATION We report a case of intra-abdominal desmoid tumor causing distal small bowel obstruction that complicated the management of a more proximal enterocutaneous fistula from the jejunum. After failure of more conventional management options including imatinib, t...

Introduction: Desmoid tumors are rare, indolent tumors of mesenchymal origin, with a potential for local invasion and adjacent organ involvement, without a metastatic potential. Pancreatic desmoid tumors are defined as tumors involving the pancreas parenchyma, sparing adjacent organs, and requiring a pancreatectomy for adequate surgical resection. Case presentation: We report a case of a lesser...

PURPOSE Constitutive activation of the Wnt signaling pathway is a hallmark of many cancers and has been associated with familial and sporadic desmoid tumors. The aim of the present study is to assess the therapeutic potential of oncolytic adenoviruses selectively replicating in cells in which the Wnt signaling pathway is active on primary cells from desmoid tumors. EXPERIMENTAL DESIGN Primary...

Four cases of desmiod tumors of the anterior abdominal wall recently treated at the University of Chicago Hospitals and Clinics are presented. From our experience we conclude: 1. Inadequate excision of desmoid tumors results in local recurrence. 2. Adequate excision of desmoid tumors ot the abdominal wall sometimes necessitates creation of an abdominal wall defect too large for primary closure....

Background: Desmoid tumors are benign and rare fibroblastic neoplasms which behave in a locally-aggressive manner to infiltrate into the adjacent tissue and have a high incidence of local recurrence after surgical excision. Desmoid tumors may develop during or shortly after pregnancy. Case presentation : We report here a case of abdominal desmoid tumor involving the ileum and its mesentery in a...

BACKGROUND Desmoid tumor is a rare type of cancer that develops in the tissues that form tendons and ligaments. These tumors, also called aggressive fibromatosis, are considered benign with no metastatic potential. They may invade nearby tissues and organs, however, and can be difficult to control. Desmoid tumor in the posterior cruciate ligament (PCL) of the knee has never been described in th...

INTRODUCTION Desmoid tumor of bone is a rare benign tumor. It is reported commonly in mandibular and meta-diaphyseal region of long bones. We report involvement of unusual site in ilio-acetabular region with breach in articular cartilage. CASE REPORT A 40 year old female presented with pain in the left hip. Radiologically, a lytic lesion at ilio-acetabular region was seen. Intra-operatively b...

BACKGROUND The clinical features and the pathological changes of desmoid tumors were studied to point out the key factors affecting the recurrence. METHODS The clinical data and specimens of 56 patients who underwent desmoid tumor resection from 2003 to 2008 were reviewed. Possible clinical factors related to the postoperative recurrence were analyzed statistically. The specimens round the le...

CONTEXT Desmoid tumors are rare, benign soft tissue tumors, characterized by the proliferation of fibroblasts in an abundant collagen extra-cellular matrix. Intra-abdominal forms involve the mesentery and retroperitoneum and usually occur associated with familial adenomatous polyposis or Gardner's syndrome. Sporadic cases are more uncommon. Although desmoid tumors do not metastasize, their evol...