Twenty-five years have passed since our group described for the first time the role played by Temperature (T) in cardiovascular stability. ‘Cold’ treatments prevented the hypotension induced by ‘warm’ treatments, whether in haemodialysis (HD) or in isolated ultrafiltration [1] or in haemofiltration [2,3]. Though some notes of caution were sounded [4], all researchers studying the problem in the...

BACKGROUND An on-line monitoring system for dialysis dose calculations could make it possible to provide an adequate dialysis dose that is consistently given to haemodialysis (HD) patients. The aim of this study was to compare dialysis dose (Kt/V) using four different methods and their sensitiveness to a reduction in clearance. METHODS Six patients were monitored on-line with ultraviolet (UV)...

Diabetes mellitus is the commonest cause of end-stage kidney failure worldwide and a proven significant risk factor for development cardiovascular disease. Renal impairment has impact on physiology glucose homeostasis as it reduces tissue sensitivity to insulin clearance. replacement therapy itself affects control: peritoneal dialysis may induce hyperglycaemia due glucose-rich dialysate haemodi...

Ferric pyrophosphate citrate (FPC) is a water-soluble iron salt administered via dialysate to supply iron directly to transferrin. The PRIME study tested whether treatment with FPC could reduce prescribed erythropoiesis-stimulating agent (ESA) use and maintain hemoglobin in hemodialysis patients. This 9-month, randomized, placebo-controlled, double-blind, multicenter clinical study included 103...

We describe a method to produce bicarbonate-based dialysates containing approximately 100 mg/dl ethanol by introducing the alcohol into one of the dialysate concentrate solutions geared for the production of bicarbonate-based dialysates.

BACKGROUND Membranes with increasing pore size are introduced to enhance removal of large uremic toxins with regular hemodialysis. These membranes might theoretically have higher permeability for bacterial degradation products. In this paper, permeability for bacterial degradation products of membranes of comparable composition with different pore size was investigated with a new in vitro set-u...

The first objective of this study was to validate the use of water at 85°C ± 5°C to achieve high-level disinfection of a clean-in-place extracorporeal dialysis circuit. The second objective was to demonstrate that applying this hot water method to the entire fluid pathways of a newly designed dialysis instrument, including an integral reverse-osmosis membrane, routinely allowed the production o...