BACKGROUND Nephropathic cystinosis is a rare inherited metabolic disorder leading to progressive renal failure and extra-renal comorbidity. The prognosis relies on early adherence to cysteamine treatment and symptomatic therapies. Developing nations [DiN] experience many challenges for management of cystinosis. The aim of this study was to assess the management characteristics in DiN compared w...

This article focuses on Mehmet Tahir Münif Paşa’s second ambassadorship to Iran (1896–1897) in the aftermath of Nasir al-Din Shah Qajar’s assassination May 1896. It argues that Shah’s death brought about a turning point Perso-Ottoman diplomatic relations and Sultan Abdülhamid’s decision assign as his representative Tehran was an affirmation new age Ottoman foreign policy. In what follows, will ...

Sitele moleculare din carbon (CMS) sunt adsorbanţi carbonici de mare importanţă. Această lucrare prezintă rezultatele studiului privind prepararea sitelor moleculare din carbon şi modificarea structurii porilor. Proprietăţile sitelor moleculare ale varietăţilor de cărbuni au fost studiate prin măsurarea capacităţii de adsorbţie dinamică a dioxidului de carbon utilizând sistemul PSA ( adsorbţia ...

We present new estimates of emissions of nitrous oxide (N2O) from rivers and estuaries, using the NEWS-DIN model. NEWS-DIN is a model of the global transport of dissolved inorganic nitrogen (DIN) by rivers to coastal waters (Dumont et al. forthcoming). It calculates DIN export rates as a function of watershed characteristics, including human influences. We used the calculated DIN export rates b...

Environmental cues transduced by an endocrine network converge on Caenorhabditis elegans nuclear receptor DAF-12 to mediate arrest at dauer diapause or continuous larval development. In adults, DAF-12 selects long-lived or short-lived modes. How these organismal choices are molecularly specified is unknown. Here we show that coregulator DIN-1 and DAF-12 physically and genetically interact to in...

the safavid era (1501–1736 ad) was the threshold of spreading security and welfare in the iranian society. the era provided the chance for the talented to set steps for advancement. one of the characters in the history of persian medicine who achieved successes in the shadow of the existing peace and security during the safavid empire was hakim imad al-din mahmud shirazi . while he was minister...

Die Normen DIN EN 61508 und DIN EN 62304 beschreiben Sicherheitsanforderungen für die Entwicklung von Software im medizinischen Umfeld. Diese beinhalten u.a. Vorschriften zur Verifikation und Diagnose (Kapitel C5, DIN EN 61508-7 [Di09]), zur Beurteilung der funktionalen Sicherheit (Kapitel C6, DIN EN 61508-7 [Di09]), zur Implementierung und Verifikation von Software-Einheiten (Kapitel 5.5, DIN ...