1-beta-d-Arabinofuranosylcytosine (ara-C), an effective drug for acute leukemias, must be phosphorylated to its 5'-triphosphate, ara-CTP, for activity. Our previous studies during therapy of acute myelogenous leukemia (AML) patients demonstrated that the accumulation of ara-CTP in circulating leukemia blasts was increased by a median of 2-fold when fludarabine (30 mg/m2/day over 30 min) was inf...

We performed studies to examine the mechanism responsible for the antithrombogenic effect of aspirin in experimental animals. We measured the effect of 10 and 100 mg/kg doses of aspirin, saiicylate, or a combination of both on the accumulation of radiolabeled platelets onto injured carotid arteries in rabbits. The effects of these agents on thrombogenecity measured as platelet accumulation onto...

The effect of different sulfate(VI) sulfur (2, 6, and 9 mM S) levels and nickel(II) chloride (0, 0.0004, 0.04 and 0.08 mM Ni) in the nutrient solution on productivity and macronutrient (N, P, K, Ca, Mg, S) status and accumulation in spring wheat (Triticum aestivum L.) Zebra cv. was studied. Ni treatment reduced the biomass and disturbed the balance and accumulation of macronutrients in wheat. I...

We performed studies to examine the mechanism responsible for the antithrombogenic effect of aspirin in experimental animals. We measured the effect of 10 and 100 mg/kg doses of aspirin, salicylate, or a combination of both on the accumulation of radiolabeled platelets onto injured carotid arteries in rabbits. The effects of these agents on thrombogenicity measured as platelet accumulation onto...

The dynamics of selenium (Se) uptake by two maize varieties (Zea mays L.) were assessed under doses (0.1 and 0.2 mg kg−1 soil) applied to the soil. addition Se increased biomass yield Se-susceptible variety (Bielik), while significantly decreasing Se-resistant (Lober), this suppression was stronger at higher dose. content also with dose, Bielik proved be more effective. In terms crop quality fo...

OBJECTIVES The primary objective was to evaluate the relationship between high-dose lorazepam and serum propylene glycol concentrations. Secondary objectives were a) to document the occurrence of propylene glycol accumulation associated with continuous high-dose lorazepam infusion; b) to assess the relationship between lorazepam dose, serum propylene glycol concentrations, and propylene glycol ...

Isoprene is a significant source of atmospheric organic aerosol; however, the oxidation pathways that lead to secondary organic aerosol (SOA) have remained elusive. Here, we identify the role of two key reactive intermediates, epoxydiols of isoprene (IEPOX = beta-IEPOX + delta-IEPOX) and methacryloylperoxynitrate (MPAN), which are formed during isoprene oxidation under low- and high-NO(x) condi...