with the aim of obtaining information about drug-drug interaction (ddi) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and controlled-potential coulometry. the reaction between n-acetyl-p-ben...

drug-drug interactions (ddis) can lead to increased toxicity or reduction in therapeutic efficacy. this study was designed to assess the incidence of potential drug interactions (pdi) and rank their clinical value in post coronary care unit (post-ccu) of a teaching hospital in tehran, iran.in this prospective study, three pharmacists with supervision of a clinical pharmacist actively gathered n...

Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...

concomitant use of several drugs by icu( intensive care unit) patients is often unavoidable. in these patients, pharmacokinetic drug interactions are very likely. the current study was designed to evaluate these interactions in patients hospitalized in an icu of a teaching hospital in tehran, iran. a questionnaire was designed and used to collect study data. the study was done in the icu of a t...

Comorbidty is common among psychiatric disorders including obsessive-compulsive disorder and schizophrenia with a high rate. Many studies suggested that the disorders may have same etiological bases. In this regard, shared pathways of glutamate, dopaminergic, and serotonin are the known ones. Here, the common significant genes are examined to understand the possible molecular origin of the diso...

     Most of the biological phenomena are influenced by intermolecular recognition and interaction. Thus, understanding the thermodynamics of biomacromolecule ligand interaction is a very interesting area in biochemistry and biotechnology. One of the most powerful techniques to obtain precise information about the energetics of (bio) molecules binding to other biological macromolecules is isoth...