PURPOSE Prostate carcinomas belong to the most widespread tumors, and their number is increasing. Imaging modalities used for diagnosis, such as ultrasound, computed tomography, and positron emission tomography, often produce poor results. Radiolabeled peptides with high sensitivity and specificity for prostate cancer would be a desirable tool for tumor diagnosis and treatment. EXPERIMENTAL D...

Though chemokines of the CXC family are thought to play key roles in neoplastic transformation and tumor invasion, information about CXC chemokines in prostate cancer is sparse. To evaluate the involvement of CXC chemokines in prostate cancer, we analyzed the CXC coding mRNA of both chemokine ligands (CXCL) and chemokine receptors (CXCR), using the prostate carcinoma cell lines PC-3, DU-145 and...

In this research, aerial parts of Euphorbia denticulata Lam were collected from Sanandaj city in Kurdistan province at the West of Iran. It was extracted by maceration using acetone as solvent. Isolation of compounds were carried out with repeated column chromatography using silica gel and normal preparative HPLC using YMC-Pack-Sil column and hexane: ethyl acetate as mobile phase. The structure...

There is accumulating evidence that some biochemical pathways observable by magnetic resonance spectroscopy, e.g., citrate acid and phospholipid metabolism, are altered in human prostate cancer. Four well-established human prostate cancer cell lines were therefore studied with magnetic resonance spectroscopy to compare differences in metabolic content with tumor biological behavior. Herein we d...

To further investigate the effect of a combination of genistein with survivin of RNA interference on the proliferation and apoptosis of DU-145 cells, the effect of genistein on the proliferation of DU-145 cells was detected by the MTT method and cytometry, and the apoptosis of cells was observed with fluorescence microscopy. In order to test combined genistein with transfection of small interfe...

Loss-of-function mutations in the nuclear factor erythroid-2-related factor 2 (Nrf2) inhibitor Kelch-like ECH-associated protein 1 (Keap1) result in increased Nrf2 activity in non-small cell lung cancer and confer therapeutic resistance. We detected point mutations in Keap1 gene, leading to nonconservative amino acid substitutions in prostate cancer cells. We found novel transcriptional and pos...

ownload g a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell h and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differactivity on cancer versus normal cells. Introduction of structural modifications yielded compound , which inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ...

ownload g a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell h and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differactivity on cancer versus normal cells. Introduction of structural modifications yielded compound , which inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ...

Downloa g a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell h and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differactivity on cancer versus normal cells. Introduction of structural modifications yielded compound , which inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ...

BACKGROUND SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteoglycans (HSPGs) located on cell surface, which are critical for the interactions with growth factors and their receptors. Alterations in SULF2 expression have been identified in th...