UDP-glucuronosyltransferase 1A10 (UGT1A10) is an extrahepatic enzyme expressed in aerodigestive tract tissues that exhibits significant glucuronidation activity against the important procarcinogenic benzo(a)pyrene (BaP) metabolite, BaP-trans-7,8-dihydrodiol (BPD), and the UGT1A10 codon 139 (Glu>Lys) polymorphism was previously implicated in risk for orolaryngeal cancer by Elahi et al. in their ...

Background: Myocardial infarction (MI) is a sever emergency and the life threatening condition if left untreated, it may be a cause of death. Objective: This study was conducted to (i) observe patients of different age groups who are mostly affected from the MI in Southern Punjab, Pakistan and (ii) evaluate various cardiac biomarkers (Troponin-T, CPK, CKMB, AST and LDH enzymes) for the detectio...

OBJECTIVE To evaluate the impact of preoperative oral trimetazidine on myocardial protection in coronary bypass surgery. METHODS We conducted a prospective double blind randomized study in the Department of Cardiac Surgery, Chaudhry Pervaiz Elahi (CPE) Institute of Cardiology, Multan, Pakistan. One hundred and seventy (170) patients of isolated CABG were included in the study. All operations ...

An increasing number of countries implement Internet censorship at different scales and for a variety of reasons. In particular, the link between the censored client and entry point to the uncensored network is a frequent target of censorship due to the ease with which a nation-state censor can control it. A number of censorship resistance systems have been developed thus far to help circumvent...

OBJECTIVE To determine the frequency of various types of ventricular septal defects (VSD) and associated complications in local paediatric population. METHODS A cross sectional descriptive study was conducted on children undergoing echocardiography in a single centre from January 2006 to December 2009 at Paediatric Cardiology Department, Ch. Pervaiz Elahi Institute of Cardiology Multan- Terti...

Texture analysis is a well-known research topic in computer vision and image processing and has many applications. Gradient-based texture methods have become popular in classification problems. For the first time we extend a wellknown gradient-based method, Co-occurrence Histograms of Oriented Gradients (CoHOG) to extract texture features from 2D Magnetic Resonance Images (MRI). Unlike the orig...

OBJECTIVES To see the early post-operative outcomes of off-pump versus on-pump coronary artery bypass graft surgery. METHODS This retrospective analytical study was conducted at Ch. Pervaiz Elahi Institute of Cardiology Multan, Pakistan. Our Primary outcome variables were; necessity of inotropic support, nonfatal myocardial infarction, ICU stay, nonfatal stroke, new renal failure requiring di...

OBJECTIVES Comparison of effectiveness and cost of transcatheter occlusion of patent ductus arteriosus (PDA) with surgical ligation of PDA. METHODS This retrospective comparative study was conducted in the pediatric cardiology department of Ch. Pervaiz Elahi Institute of Cardiology Multan, Pakistan. Data of 250 patients who underwent patent ductus arteriosus (PDA) closure either surgical or t...

We have suggested the existence of a novel "constitutive-like" secretory pathway in pancreatic islets, which preferentially conveys a fraction of newly synthesized C-peptide, insulin, and proinsulin, and is related to the presence of immature secretory granules (IGs). Regulated exocytosis of IGs results in an equimolar secretion of C-peptide and insulin; however an assay of the constitutive-lik...