Esophageal squamous cell carcinoma and esophageal adenocarcinoma are cancers of high mortality. EAC develops through Barrett's esophagus (BE) and columnar dysplasia, preceded by gastro-esophageal reflux disease. The risk of esophageal squamous cell carcinoma is increased by smoking and alcohol consumption. New treatment options for esophageal cancer are desperately needed. Toll-like receptors (...

Golestan Province in northeastern Iran has one of the highest rates of esophageal squamous cell cancer in the world. This article reviews the studies conducted on esophageal squamous cell cancer in this area and summarizes the data on epidemiologic patterns, incidence trends, and etiology of esophageal squamous cell cancer in this province.

PURPOSE MicroRNAs are approximately 22 nucleotide noncoding RNA molecules that posttranscriptionally regulate gene expression. The aim of this study was (a) to determine a role of microRNA-21 in esophageal squamous cell carcinoma and (b) to elucidate the regulation of the programmed cell death 4 (PDCD4) gene by microRNA-21. EXPERIMENTAL DESIGN MicroRNA-21 expression was investigated in 20 mat...

esophageal cancer is the ninth most common malignancy.the incidence of esophageal cancer varies greatly among regions of the world and occurs at a high frequency in asia and northern iran. we report the case of an 80-year-old man with esophageal squamous cell carcinoma who initially presented with a metastatic scalp lesion. esophagoscopy was performed and a lesion was located in the mid-portion...

BACKGROUND Leukotriene B4 (LTB4R and LTB4R2) and cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2) contribute to malignant cell transformation. We aimed to investigate the expression of LTB4R, LTB4R2, CYSLTR1 and CYSLTR2 in esophageal squamous cell carcinoma and adjacent non-transformed squamous epithelium of the esophagus, as well as in control biopsy samples from esophageal squamous epith...

introduction and aims: the role of human papillomavirus (hpv) in the etiology of esophageal squamous cell carcinoma (escc) is not clear. previous studies have found highly variable (from 0% to 67%) prevalence of hpv in escc tumor. however, prevalence of hpv in escc tumor seems to be higher in areas with high incidence of escc , such as china and south africa. iran is one of the areas of the wor...

objective(s):  cd44 is a member of the cell adhesion molecules family. naturally, cd44s, along with cd44v3 influence the cell motility, migration, and adhesion, while in tumor cells they lead to tumor invasion, progression, and metastasis. the purpose of this research is to evaluate the cd44s and cd44v3 expression in esophageal squamous cell carcinoma (escc) and to reveal their correlations wit...

High levels of angiogenesis are associated with poor prognosis and a highly invasive phenotype in esophageal squamous carcinoma. C-C chemokine receptor type 7 (CCR7) is overexpressed in multiple tumor types and has been suggested to act as an oncogene and pro-angiogenic factor. This study aimed to elucidate the effect of CCR7 on the angiogenic capacity of esophageal squamous carcinoma cells in ...

BACKGROUND This study was trying to investigate the association of hot food and beverage consumption and the risk of esophageal squamous cell carcinoma in Hotan, a northwest area of China with high risk of esophageal squmous cell carcinoma. METHODS A population-based case-control study was designed. For the study, 167 patients diagnosed with esophageal squamous cell carcinoma were selected fr...

This study describes recent trends in incidence, survival and prevalence of subgroups of esophageal and gastric cancer in Linzhou city between 2003 and 2009. Data of esophageal and gastric cancer for the period of interest were extracted from the Linzhou Cancer Registry. Using information on tumor morphology or anatomical site, data were divided into six groups; esophageal squamous cell carcino...