to understand the mechanism of multiple sclerosis (ms), an autoimmune demyelinating disease, the researchers developed an experimental animal model for ms, which is called eae (experimental allergic encephalomyelitis). there are several methods for inducing this animal model. in this research the active eae, which is developed by injecting bovine myelin antigens into genetically susceptible ani...

The Duffy antigen/receptor for chemokines, DARC, belongs to the family of atypical heptahelical chemokine receptors that do not couple to G proteins and therefore fail to transmit conventional intracellular signals. Here we show that during experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, the expression of DARC is upregulated at the blood-brain barrier. These fi...

OBJECTIVES To research the effects of transplanting mesenchymal stem cells on the development of experimental autoimmune encephalomyelitis and the mechanism behind it. MATERIALS AND METHODS An experimental autoimmune encephalomyelitis animal model was induced by injection of the MOG peptide, and mesenchymal stem cell injection was done 20 and 22 days after experimental autoimmune encephalomye...

several religions recommend periods of fasting. one of the most frequently asked questions of ms patients before the holy month of ramadan is weather fasting might have an unfavorable effect on their disease course. this debate became more challenging after the publication of experimental studies suggesting that calorie restriction prior to disease induction attenuates disease severity. we cond...

background and objectives: multiple sclerosis is an inflammatory disease of the central nervous system. this is due to migration of peripherally activated lymphocytes to central nervous system leading to inflammatory lesions. however, liver has an anti-inflammatory microenvironment. myelin expression in the liver of transgenic mice suppresses inflammatory lesions within central nervous system. ...

Experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) disease are two demyelinating diseases of the central nervous system (CNS) that serve as animal models for multiple sclerosis. Th1 cells are thought to play a role in the pathogenesis of CNS demyelination in both these diseases. We show here the differential influence of interleukin 12, a critical ...