We used concanavalin A crossed-line affinity immunoelectrophoresis to determine the percentage of concanavalin A nonreactive alpha-fetoprotein in amniotic fluid samples from pregnancies with normal and abnormal fetuses. In 167 samples from pregnancies with a normal outcome and normal values for total alpha-fetoprotein concentration in amniotic fluid the percentage decreased from a median value ...

The California Supreme Court first recognized wrongful life in Turpin v. Sortini, and has since only permitted the child to recover special damages for the extraordinary additional medical care and training occasioned by the genetic defect. The wrongful life jury instruction under CACI requires the following elements to sustain the cause of action: 1) the defendant negligently failed to diagnos...

BACKGROUND Pediatric germ cell tumors account for approximately 3.5 % of all childhood cancers for children under the age of 15 years. Up to one-third are extragonadal neoplasms. Germ cell tumors are a heterogeneous group of malignant tumors with a wide variety of histopathological features. Yolk sac tumor is the predominant variant in newborns and younger children. We report for the first time...

AIMS Hepatocellular carcinoma is one of the most aggressive malignant tumors and has limited treatment options. Needle-guided biopsies have been utilized as a tool to diagnose malignant focal hepatic lesions. These techniques are discouraged because of their complications. Nowadays, alpha fetoprotein is the most widely used tumor marker for screening and diagnosis of hepatocellular carcinoma. N...

An endogenous chromophore regularly associated with rat alpha 1 fetoprotein was detected by a systematic study of the fluorescence spectra of the protein purified by immunoabsorption. This fluorescent ligand, of low molecular weight, was dissociated from rat alpha 1 fetoprotein by exhaustive dialysis of the protein at low concentration. A phase partition method with aqueous preparations of rat ...

We have analyzed the DNasel sensitivity of chromatin from the rat albumin and a-fetoprotein genes in the fetal liver (which synthesizes albumin and a-fetoprotein), adult liver (which synthesizes albumin), fetal yolk sac (which synthesizes -fetoprotein), and adult kidney (which synthesizes neither). Active genes were much more sensitive than their kidney counterparts, and the adult liver a-fetop...