The purposes of this review are to assess the human exposure and human and experimental evidence for adverse effects of brominated flame-retardants (BFRs) with specific focus on intake from seafood. The leakage of BFRs from consumer products leads to exposure of humans from fetal life to adulthood. Fish and fish products contain the highest levels of BFRs and dominate the dietary intake of freq...

OBJECTIVE The beneficial effect of dietary fish oil, rich in omega-3 polyunsaturated fatty acids (PUFAs), on cardiovascular disease is multifactorial and may partly rely on their anticoagulant action. We studied how fish oil intake influenced thrombin generation in plasma and which factors were involved herein. METHODS AND RESULTS Twenty-five healthy males with borderline overweight received ...

BACKGROUND Increasing laboratory findings indicate that n-3 fatty acids, mainly derived from fish, inhibit cancer development and progression, but results from epidemiologic studies have been inconsistent and inconclusive. OBJECTIVE To evaluate the association of fish intake with risk of liver cancer by conducting a meta-analysis. METHODS Published case-control/cohort studies that evaluated...

OBJECTIVES Our aim was to investigate the relation between fish consumption and incidence of congestive heart failure (CHF). BACKGROUND The incidence and health burden of CHF are rising, particularly in older persons. Although n-3 fatty acids have effects that could favorably influence risk of CHF, the relation between fish intake and CHF incidence is unknown. METHODS Among 4,738 adults age...

Fish and long-chain ω-3 polyunsaturated fatty acid (LCω3PUFA) intake in relation to the risk of cardiovascular diseases have been well studied. However, studies that directly link fish consumption or LCω3PUFA intake to the risk of metabolic syndrome (MetS) are sparse and the results are inconsistent. We reviewed literature through December 2014 and used random-effects or fixed-effects models, a...

ment, including objective biomarkers of fish intake such as marinederived fatty acids, vitamin D and toxins, where appropriate’’ (1). We were also careful not to make direct comparisons between the effect sizes for fatty fish and total fish and offered the effect of long-chain omega-3 (n–3) PUFAs as one plausible hypothesis, emphasizing that this needs further testing in future studies. We note...

High intake of fish and (n-3) PUFA may protect against age-related cognitive decline. However, results are inconsistent and limited data exist regarding changes in multiple cognitive functions over a longer period of time. In this study, we assessed the association between fatty fish intake as well as (n-3) PUFA intake with cognitive performance and cognitive change over 6 y in 1025 elderly men...

BACKGROUND Although fish intake can improve glucose metabolism, results of some prospective studies in Western populations suggest potential adverse effects of environmental contaminants in fish on type 2 diabetes risk. However, data from populations with high fish consumption are scarce. OBJECTIVE We prospectively investigated the association between fish intake and type 2 diabetes risk in J...

Several studies have investigated the potential benefits of marine n-3 PUFA in CVD, generally suggesting a lower risk of CHD. However, recent trials have questioned these results. This study investigated the association of fish consumption with dietary intake of marine n-3 PUFA with incident myocardial infarction (MI). In a Danish cohort study, 57 053 subjects between 50 and 64 years of age wer...