BACKGROUND Triple negative breast cancer (TNBC) in humans is defined by the absence of oestrogen receptor (ER), progesterone receptor (PR) and HER2 overexpression. Mammalian target of rapamycin (mTOR) is overexpressed in TNBC and it represents a potential target for the treatment of this aggressive tumour. Feline mammary carcinoma (FMC) is considered to be a model for hormone-independent human ...

We compare two approaches for a Markovian model in flexible manufacturing systems (FMSs) using Monte Carlo simulation. The model which is a development of Fazlollahtabar and Saidi-Mehrabad (2013), considers two features of automated flexible manufacturing systems equipped with automated guided vehicle (AGV) namely, the reliability of machines and the reliability of AGVs in a multiple AGV jobsho...

this article addresses a single row facility layout problem where the objective is to optimize the arrangement of some rectangular facilities with different dimensions on a line. regarding the np-hard nature of the considered problem, a hybrid meta-heuristic algorithm based on simulated annealing has been proposed to obtain a near optimal solution. a number of test problems are randomly generat...

Companion animal spontaneous tumors are suitable models for human cancer, primarily because both animal population and the tumors are genetically heterogeneous. Feline mammary carcinoma (FMC) is a highly aggressive, mainly hormone receptor-negative cancer, which has been proposed as a model for poor prognosis human breast cancer. We have identified and studied the feline orthologue of the HER2 ...

Because of their flexibility, controllability and convenience, Automated Guided Vehicles (AGV) have gradually gained popularity in intelligent manufacturing because to adaptability, controllability, simplicity. We examine the relationship between AGV scheduling tasks, charging thresholds, power consumption, order address issue how affects flexible units with multiple AGVs. Aiming promote AGVs l...

Fixed mobile convergence (FMC) will be one of the strongest trends in telecommunications in the near future. Given the choice, most consumers would want to use a single handset yet do not want to pay the premium when at home or in the office. Even though seamless network integration will still take some time to become reality, there are many convergence opportunities that are currently being ex...

The frequency of mutant T cells (FMC) in blood lymphocytes from patients with systemic lupus erythematosus (SLE) was measured by growing cells in the presence and in the absence of 6-thioguanine. Patients with SLE had a spectrum of FMC ranging from normal to about 100 times normal. This high FMC among cells from SLE patients appears to reflect excessive in vivo activation and proliferation duri...

Domestic cats share human living environments and genetic traits. They develop spontaneous feline mammary carcinoma (FMC) with similar histopathology to human breast cancer. HER2 and AKT phosphorylation was demonstrated in primary FMC by immunoblot analysis, indicating HER2 as a therapeutic target. FMC lines K12 and K248 expressing HER1, HER2, and HER3 were sensitive to receptor tyrosine kinase...