This paper describes a simple and deterministic method for modelling and designing a flow manufacturing system, especially well suited for SMEs. The paper covers five themes: A brief review the history of flow manufacturing, a comparison of the flow manufacturing approach with other existing improvement approaches, a proposal of crucial design principles for flow manufacturing, a method for sim...

The typical problems facing garment manufacturers are long production lead time, bottlenecking, and low productivity. The most critical phase of garment manufacturing is the sewing phase, as it generally involves a number of operations or for the simple reason that it’s labor intensive. In assembly line balancing, allocation of jobs to machines is based on the objective of minimizing the workfl...

Lean manufacturing is a production philosophy made popular by Toyota Motor Corporation (TMC). It is globally known as the Toyota Production System (TPS) and has the ultimate aim of reducing cost by thoroughly eliminating wastes or muda. TPS embraces the Just-in-time (JIT) manufacturing; achieving cost reduction through lead time reduction. JIT manufacturing can be achieved by implementing Pull ...

This paper presents a new software tool for automatic creation of simulation models for flow lines. The tool was developed in a general way. The tool was applied to the production flow line at the rolling stock Company Bombardier Transportation Portugal, SA, in Amadora, in order to develop its simulation model. Information regarding manufacturing philosophies, flow assembly lines, production sc...

The most important models and results of the manufacturing flow line literature are described. These include the major classes of models (asynchronous, synchronous, and continuous); the major features (blocking, processing times, failures and repairs); the major properties (conservation of flow, flow rate-idle time, reversibility, and others); and the relationships among different models. Exact...

background: lactoferrin (lf) is a glycoprotein, a member of the transferrin family.from ten known mechanisms of anti-cancer chemoperotecive compounds, lf alone, has six of these functions and inhibits cancer. in this study, the effect of lactoferrin purified from bovine colostrum was studied as an anti-cancer agent on esophageal cancer cell line. materials and methods: bovine colostrum were col...

The problem of production flow in the manufacturing line is analyzed. The machines can be operated by workers or by robots. Since breakdowns and human factors affect the destabilization of the production processes, robots are preferred to apply. The problem is how to determine the real difference in work efficiency between human and robot. Analysis of the production efficiency and reliability o...

Cleaning validation, a requirement of the current Good Manufacturing Practices (cGMP) for Drugs, consists of documented evidence that cleaning procedures are capable of removing residues to predetermined acceptance levels. This report describes a strategy for the selection of the worst case product for the production of lyophilized reagents (LRs) for labeling with 99mTc from the Instituto de Pe...

This paper presents to determine the optimum number of kanbans in Generalized Kanban Control System (GKCS) at three different demand frequencies and keeping the mean processing time as constant. The configuration of the single line with three manufacturing stages is assumed to have flow line production. The manufacturing system is modeled as network diagram of GKCS using discrete event simulati...

A flow line is a conventional manufacturing system where all jobs must be processed on all machines with the same operation sequence. Line buffers allow non-permutation flowshop scheduling (NPFS) and job sequences to be changed on different machines. A mixed-integer linear programming model for non-permutation flowshop scheduling and the buffer requirement along with manufacturing implication i...