نتایج جستجو برای: fluconazole sensitive c albicans
تعداد نتایج: 1317389 فیلتر نتایج به سال:
Abstract Background and objectives: Genital tract infections are among the most common causes of patients referred to therapeutic centers. Nearly 75% of women suffer from genital Candida infection, at least once in their lifetime. The aim of present study was detection of Candida species causing vaginitis and the evaluation of antimycotic effects of ketoconazol, clotrimazole and fluconazole aga...
The epidemiology and clinical significance of fluconazole resistance were assessed in a cohort of advanced human immunodeficiency virus (HIV)-infected patients with recurrent oropharyngeal candidiasis. Fifty patients were prospectively evaluated using a novel method of detecting fluconazole resistance with chromogenic media containing fluconazole; results were confirmed with macrobroth testing....
Background and Aim: Onychomycosis is an infection caused by yeast, filamentous and non-filamentous fungi, due to diverse conditions. This study aimed to investigate the pattern of azole susceptibility of candidate species isolated from Iranian patients in Tehran. Methods: After sampling from patients, identification of the isolated strains were performed with Candida chrom agar medium and PC...
This study evaluates the effects of cytokines, used singly and in combination, on the microbicidal activity of human monocyte-derived macrophages (MDM) against intracellular Candida albicans in the presence and absence of fluconazole. In the absence of fluconazole, the addition of tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), gamma interferon (IFN-gamma), or IL-4 had no...
BACKGROUND The ability of Candida albicans to form biofilms and adhere to host tissues and biomaterial surfaces is an important factor in its pathogenesis. One of the main characteristics of biofilms is their resistance to broad-spectrum anti-microbial drugs. OBJECTIVES In the present study the formation of biofilm by C. albicans from different sources was evaluated. In addition, the minimum ...
Background and Aims: Candida albicans as an opportunistic fungal pathogen in human is the cause of volvovaginitis candidiasis. Azole resistance is cinsiderable as worldwide problem in treatment of candidiasis. Azole resistance can occur through different mechanisms such as mutation in ERG11 gene. The aim of our study was evaluation of ERG11 gene mutations in fluconazole resistant islotes of C. ...
Background & Objective: Candidiasis has gained importance due to its increasing prevalence in immunocompromised patients. Antifungal drugs such as fluconazole and amphotericin B are used for the treatment of candidiasis. One of the biggest problems faced in clinical practice is resistance for most of these drugs. The antifungal drugs derived from natural products have helped to overcome this pr...
Constitutive overexpression of the MDR1 (multidrug resistance) gene, which encodes a multidrug efflux pump of the major facilitator superfamily, is a frequent cause of resistance to fluconazole and other toxic compounds in clinical Candida albicans strains, but the mechanism of MDR1 upregulation has not been resolved. By genome-wide gene expression analysis we have identified a zinc cluster tra...
conclusions caspofungin appears more effective in vitro against iranian fluconazole-resistant candida isolates and some other yeasts. results the most frequently isolated species were candida albicans (52.2%), c. glabrata (24.6%), followed by c. tropicalis (7.7%) and c. krusei (3.4%). mics of caspofungin against 87% of c. albicans and 90% of c. glabrata and c. tropicalis isolates were 2 μg/ml a...
The aim of this study was to evaluate the activity of fluconazole against 32 clinical strains of fluconazole-resistant Candida albicans, and C. albicans ATCC 10231 reference strain, after their exposure to sublethal concentrations of tea tree oil (TTO) or its main bioactive component terpinen-4-ol. For all tested fluconazole-resistant C. albicans strains TTO and terpinen-4-ol minimal inhibitory...
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