Matrix metalloproteinases (MMPs) degrade various components of the extracellular matrix and functional polymorphisms in encoding genes may contribute to genetic susceptibility to many cancers. Up to now, associations between MMP-7 (-181A>G) and digestive system cancer risk have remained inconclusive. To better understand the role of the MMP-7 (-181A>G) genotype in digestive cancer development, ...

OBJECTIVES The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. MATERIALS AND METHODS From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high HOMR-IR, and low HOMR-IR). Two PCR products of LEP were sequenced and aligned...

Aims: To investigate the impact of P-selectin (SELP) genetic polymorphisms and its interaction with smoking on cardiovascular disease (CVD) risk based on Chinese population. Methods: A total of 1082 subjects (519 males, 563 females), with a mean age of 53.9±13.1 years old, were selected, including 540 CVD patients and 542 normal control participants. Logistic regression model was used to examin...

OBJECTIVE To investigate the relationship between excision repair cross-complementing group 1 (ERCC1)-4533/8092, tumor necrosis factor-alpha (TNF-α)-238/308 polymorphisms, and the risk of hepatocellular carcinoma (HCC) in Guangxi Zhuang population of China. METHODS Polymerase chain reaction-restriction fragment length polymorphism method was used to detect the ERCC1-4533/8092 and TNF-α-238/30...

T umor necrosis factor (TNF)is an integral part of the immune response to infection. A number of polymorphisms in or near the TNFgene are associated with variability in TNFproduction. The three polymorphisms with the best documented in vivo and in vitro effect on TNFproduction are the TNF-238, TNF308, and lymphotoxin (LT)250 loci. At each locus, a G to A transition is associated with greater TN...

BACKGROUND To assess the association between tumor necrosis factor-alpha (TNF-α) G308A, G238A and C863T polymorphisms and hepatitis B virus related hepatocellular carcinoma (HBV-HCC) susceptibility. METHODS We interrogated the databases of Pubmed, Sciencedirect and Viley online library up to March 8, 2016. Odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) were calculated i...

MicroRNAs (miRNAs) are key regulators of gene expression and play an important role in the development and progression of various diseases including esophageal squamous cell carcinoma (ESCC). In this study, we determined whether a polymorphism at the miR-214 binding site in the 3'-untranslated region (3'-UTR) of the methylenetetrahydrofolate reductase gene (MTHFR) is associated with susceptibil...

Background: Pathophysiology of type 2 diabetes mellitus (T2DM) is influenced by the complex interaction several genes that regulate energy metabolism in body. Several polymorphisms occur many gene encode components glucose regulation are significantly implicated onset T2DM.Methods: This case-control study. Case group with 58 subjects T2DM patients obesity and a control non-DM obese from ethnic ...