The objective of the current study was to investigate the significance and biologic characteristic of neuroendocrine cell differentiation (NED) in gastric carcinoma by comparing the prognosis and clinicopathologic characteristics between patients with or without NED. Retrospective analyses of neuroendocrine markers, neuron specific enolase (NSE), chromogranin A (CgA), and synaptophysin (Syn) we...

Gastric signet ring cell carcinoma (GSRCC) is an important histological type of gastric cancer. Its biological and clinical particularities distinguish it from other cancers in ways that require tailored management decision-making. This short review provides overview what known about this prevalent entity, highlights recent developments the research surrounding GSRCC, covers microbiome, immunol...

OBJECTIVE To investigate the relation of Fas and Fas ligand (FasL) protein expression with carcinogenesis and metastasis of cardiac carcinoma. METHODS Immunohistochemistry was used to detect Fas and FasL protein expression in 64 cardiac carcinoma tissue samples and 20 normal gastric tissue samples. Relation between FasL and Fas expression, age and gender of gastric cancer patients, and pathol...

Gastric cancer is the fourth most common cancer and the second cause of cancer-related death worldwide . Various types of gastric cancers differ in their epidemiology, pathogenesis, genetic profile and clinical outcome . There has been the overall decline in the total incidence of gastric cancer in the last few decades worldwide, but the decline of signet ring cell (SRC) type of gastric carcino...

OBJECTIVE To note the association of Helicobacter pylori in patients having carcinoma of stomach. METHODS A descriptive study was carried out at the Department of Histopathology, Ziauddin Medical University, Karachi from April 1992 to May 1998. Histological evaluation of 50 cases of carcinoma of stomach was compared with 50 cases each of chronic gastritis and histological normal gastric mucos...

The skin is an unusual location for métastases from visceral carcinoma, and cutaneous métastases from gastric carcinoma are rare. Cutaneous métastases display various clinical features, but usually occur as non-specific firm nodules. However, no cases of occult métastases from gastric carcinoma have been reported. We describe here a patient with clinically unapparent cutaneous metastasis fi^om ...

Gastric lymphoepithelioma-like carcinoma is a rare carcinoma among gastric malignant tumor but has a good prognosis. The carcinoma has histologic feature characterized by small nest of cancer cells mixed with lymphoid stroma. We report a case with lymphoepithelioma-like carcinoma of stomach initially presenting as panperitonitis because of spontaneous tumor perforation. A 56-year-old man visite...

The prevalence of circulating antibodies to gastric intrinsic factor and parietal cells was examined in 60 patients with histologically proven gastric carcinoma and was found not to differ from the prevalence of these antibodies in control subjects of similar age and sex distribution.Amongst the 60 patients with gastric carcinoma seven were thought to have actual or potential pernicious anaemia...

The aim of the study was to ascertain the existence of intestinal metaplasia in gastric mucosa of patients with gastric carcinoma coupled with H. pylori positive chronic atrophic gastritis and possible connection of IM with the development of gastric carcinoma. The paper presents prospective study that included 50 patients with gastric carcinoma and 50 patients with chronic atrophic H. pylori p...

Gastric carcinoma is highly prevalent throughout the world. Understanding the pathogenesis of this disease will benefit diagnosis and resolution. Studies show that miRNAs are involved in the tumorigenesis of gastric carcinoma. An initial screening followed by subsequent validation identified that miR-376c is up-regulated in gastric carcinoma tissue and the plasma of patients with the disease. I...