Bioactive products from snail slime of “Helix” specie have potential applications in preventing and/or treating several human diseases and in cancer diagnosis. However, the poor pharmacokinetics characteristics of these natural compounds limit their use. Nanotechnology offers promising solutions for the enhanced formulation of these molecules through the synthesis of nanosized drug del...

The condition for axial mode operation in helical antenna according to the classical design data is the helix circumference to wavelength ratio (C/ ) must be in a range of 0.8 to 1.2. In this paper the C/ ratio is reduced to 0.2 for the wavelength 125 mm. It is achieved by loading the helix in a back cavity. The design concept of helical resonator filter is used for design of this antenna. If t...

In classical differential geometry, the problem of the determination of the position vector of an arbitrary space curve according to the intrinsic equations κ = κ(s) and τ = τ (s) (where κ and τ are the curvature and torsion of the space curve ψ, respectively) is still open [7, 14]. However, in the case of a plane curve, helix and general helix, this problem is solved. In this paper, we solved ...

This study numerically investigated heat transfer and fluid flow characteristics in a novel cylindrical heat sink with helical minichannels for the laminar flow of fluid with temperature-dependent properties. A finite volume method was employed to obtain the solution of governing equations. The effects of helical angle, channel aspect ratio, and Reynolds number, which were regarded as main para...

The stability behavior of low immersion helical end milling processes is investigated in this paper. Low radial immersion milling operations involve interrupted cutting which induces chatter vibration under certain cutting conditions. Time Finite Element Analysis (TFEA) is suggested for an approximate solution for delayed differential equations encountered during interrupted milling. An improve...

Molecular dynamic simulation is a powerful method that monitors all variations in the atomic level in explicit solvent. By this method we can calculate many chemical and biochemical properties of large scale biological systems. In this work all-atom molecular dynamics simulation of polyalanine (PA) was investigated in the presence of 0.224, 0.448, 0.673, 0.897 and 1.122 M of guanidinium chlorid...

To help elucidate the general rules of globular protein folding, computer simulations of the conformational transition in model proteins having the left-handed, four-helix bundle motif in which the helices are joined by one or two long loops, as in apoferritin and somatotropin, respectively, have been undertaken. In the context of simple tetrahedral lattice protein models, these unique native h...

HJ1, a 42-residue peptide that folds into a helix-loop-helix motif and dimerizes to form a four-helix bundle, successfully catalyzes the cleavage of "early stage" DNA model substrates in an aqueous solution at pH 7.0, with a rate enhancement in the hydrolysis of heptyl 4-nitrophenyl phosphate of over three orders of magnitude over that of the imidazole-catalyzed reaction, k(2)(HJ1)/k(2)(Im) = 3...