Gentamicin is an important aminoglycoside antibiotic. However its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. There are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....

Background: Gentamicin causes nephrotoxicity and ototoxicity using megalin as a key cellular uptake-site, but no structural data are available Results: Gentamicin binds to megalin with low affinity and exploits the common ligand binding motif Conclusion: This first structure of human megalin in complex with gentamicin suggest electrostatics to be the main binding determinant Significance: Struc...

Oleo-gum-resin of Boswellia serrata Roxb. (Burseraceae) locally called ‘Kundur’, is one of the ingredients in certain Unani formulations used in renal diseases. In the present study, the effect of Kundur and its methanol soluble (MS), and methanol insoluble (MINS) fractions were investigated on Gentamicin induced nephrotoxicity in Albino rats. The renal effects of Kundur and its fractions were ...

Aminoglycoside antibiotics, especially gentamicin, are widely used to treat Gram-negative infections due to their efficacy and low cost. Nevertheless the use of gentamicin is limited by its major side effect, nephrotoxicity. Xenon (Xe) provided substantial organoprotective effects in acute injury of the brain and the heart and protected against renal ischemic-reperfusion injury. In this study, ...

Gentamicin (GM) is widely used for treatment of severe gram negative infections; however its clinical use is partially limited due to its nephrotoxicity. This study aimed to evaluate the protective role of N-acetylcysteine (NAC) and vitamin E on gentamicin-induced nephrotoxicity. Forty adult male albino rats were divided into equal five groups, Group1: normal control administered standard diet ...

Gentamicin (GM) is a widely used antibiotic against serious and life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rats. Quantitative evaluation of gentamicin-induced structural alterations and degree of functional alterat...

Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity. Sildenafil, a selective phosphodiesterase-5 inhibitor, was reported to prevent or decrease tissue injury. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicin-induced nephrotoxicity in rats...

Gentamicin is an important aminoglycoside antibiotic. However its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. There are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....