Cold-insoluble globulin (CI globulin) was purified from human plasma and identified on the basis of its sedimentation coefficient, electrophoretic mobility, and concentration in normal plasma. CI globulin was distinguished from antihemophilic factor (AHF) by amino acid analysis, position of elution from 4% agarose, and electrophoretic migration in polyacrylamide gels in the presence of sodium d...

This doctoral thesis is based on seven previously published papers and reports on the role of the actin-scavenger Gc-globulin in acute and chronic liver diseases. Gc-globulin is synthesized in the liver and is a multifunctional protein; however, its main physiologic function is presumably actin binding and actin scavenging. Actin is a major cellular protein released during cell necrosis that ma...

Highly purified C'1 esterase of human serum is capable of inactivating isolated fourth component of human complement (beta(1E)-globulin). Inactivation is accompanied by changes in electrophoretic and ultracentrifugal properties of beta(1E)-globulin. If non-sensitized sheep erythrocytes are present during the action of C'1 esterase on beta(1E)-globulin, a complex is formed consisting of cells an...

Cold-insoluble globulin (CI globulin) was purified from human plasma and identified on the basis of its sedimentation coefficient, electrophoretic mobility, and concentration in normal plasma. CI globulin was distinguished from antihemophilic factor (AHF) by amino acid analysis, position of elution from 4% agarose, and electrophoretic migration in polyacrylamide gels in the presence of sodium d...

The objectives of this study were to evaluate the serum protein electrophoresis pattern in dogs infected with B. canis, and correlation between haematocrit and albumin/globulin ratio. The infection with B. canis was confirmed by PCR and sequencing of PCR products. Total serum protein concentrations were determined by a clinical chemistry analyser. Albumin, α1-, α2-, β1-, β2-, and γ-globulin con...

abstract background immune thrombocytopenic purpura (itp) is the most prevalent cause of thrombocytopenia in children. despite the importance of itp in children under 2- years old, only a few publications are available in the literature. itp usually presents itself as   isolated thrombocytopenia and mucocutaneous bleeding. materials and methods this study was conducted on 187 under 2- year-old ...

In rabbits hyperimmunized with pneumococcal vaccine high concentrations of gamma globulin are produced. In such rabbits, plasma volume was determined with (131)I-labelled rabbit albumin and red cell volume with (51)-Cr-labelled autologous red cells. It was found that the plasma volume increased with increasing gamma globulin concentration, the highest values observed being about 10 gm. per cent...

By ROBERT E. ANDERSON AND Ro L. WALFORD T HE PRESENT study forms part of a continuing effort to develop quantitative methods for detecting antigen-antibody reactions involving nucleated cells as antigen. Here we shall present information regarding the preparation of purified, 1131-labelled anti-human-globulin antibody (AHG antibody) by means of adsorption and elution from normal human globulin,...

For treatment of severe aplastic anemia, immunosuppressive therapy with horse antithymocyte globulin results in superior response and survival compared with rabbit antithymocyte globulin. This relative benefit may be different in the setting of transplantation as rabbit antithymocyte globulin results in more profound immunosuppression. We analyzed 833 severe aplastic anemia transplants between ...