Background: Cardiac complications due to iron overload are the most common cause of death in patients with thalassemia major. The aim of this study was to compare iron chelation effects of deferoxamine, deferasirox, and combination of deferoxamine and deferiprone on cardiac and liver iron load measured by T2* MRI. Methods: In this study, 108 patients with thalassemia major aged over 10 years...

Twelve anesthetized mongrel dogs underwent left thoracotomy with placement of a removable ligature around the left circumflex coronary artery. Following a 3 to 6 hour delay, ECG-gated spin-echo MRI was performed. The ligature was then removed reperfusing the heart, and after a 10-15 min period, MRI repeated. Finally, post-sacrifice images were obtained, and the hearts chemically stained for inf...

conclusion adrenal iron in β-tm can be reliably measured in 3 tesla mri. the results highlight the absence of correlation between adrenal iron deposition both with serum ferritin and hepatic iron. results among patients, there was no significant correlation between plasma ferritin and adrenal t2*. significant difference was detected among t2* values of adrenals between the patient and control g...

BACKGROUND Heart failure resulting from myocardial iron deposition is the most important cause of death in β-thalassemia major (TM) patients. Cardiac T2*magnetic resonance imaging (MRI), echocardiography, and serum ferritin level serve as diagnostic methods for detecting myocardial iron overload. In this study, we aimed to evaluate the relationship between the above-mentioned methods. METHODS...

Background: Iron accumulation in organs such as heart and liver can cause morbidity and mortality in transfusion-dependent patients with β-thalassemia major. MRI T2* relaxometry has been increasingly used in clinical practice for quantitative assessment of iron overload in heart and liver. For a heavily iron loaded liver, T2* is ultra-short (<1ms). In this scenario, conventional gradient echo s...

BACKGROUND Early detection of heart failure is essential to effectively reduce related mortality. The quantification of the mechanical properties of the myocardium, a primordial indicator of the viability of the cardiac tissue, is a key element in patient's care. Despite an incremental utilization of multi-parametric magnetic resonance imaging (MRI) for cardiac tissue characteristics and functi...

Introduction: Thalassemia major (TM) patients require lifelong iron load monitoring to assess the effectiveness of chelation therapies. Multiecho T2* MRI is a well established technique for heart and liver iron overload assessment [1]. There are few reports on the use of MRI to study iron deposits in the pancreas. The aims of this study were to describe the T2* values of the pancreas in patient...

OBJECTIVES We sought to evaluate whether echocardiographic diastolic function indices correlate with myocardial iron and systolic function in patients with transfusion-dependent thalassemia (TDT) who are at risk for cardiomyopathy. BACKGROUND In thalassemia syndromes, there is an important clinical need to risk stratify patients for the development of iron-overload cardiomyopathy so that chel...