poliomyelitis, an acute viral infectious disease caused by poliovirus, still remains a public health problem in developing countries. despite the global effort to eradicate polio, continuing the polio immunization with a potent and safe vaccine is essential. for accurate vaccine evaluation, three types of cell lines including hela, hep2c and vero were evaluated and compared using two methods of...

doxorubicin is a broad spectrum antibiotic used in the treatment of cancers. its dose dependent cardiotoxicity is the most serious side effect causing withdrawal of drug from hard chemotherapeutic regimen. statins are shown to be cytotoxic in concentrations higher than the effective doses for the treatment of hypercholesterolemia (40 mg/day). co-administration of statins and chemotherapeutic ag...

Cisplatin (DDP)‑based chemotherapy is a standard treatment for cervical cancer, although resistance remains major concern. Hypoxia‑inducible factor‑2 α (HIF‑2α) plays an important role in resistance. MicroRNAs (miRs) can inhibit gene expression by binding to the 3'‑untranslated region of target gene. The authors' previous study showed that miR‑519d‑3p regulation HIF‑2α under hypoxic conditions ...

amphiphilic cationic micelles have recently attracted much attention as non-viral vector. in the current study the retinoic acid-g-chitosan (ra-chitosan) micelles have been used as novel gene carriers. uptake of micelles, condensation ability and transfection efficiency of micelle–dna complexes (miceplexes) in the presence or absence of serum had been investigated on hela and hepg2 cell lines. ...

2,6-Pyridinediylbisalkanamides were synthesized, using diaminopyridine (DAP) as a linker and alkyl chains of varying lengths, that upon self-assembly form submicron-sized sheets and their uptake into the cytoplasm of HeLa cells was studied by confocal microscopy.

it has been reported that latex and extracts of different species of ficus are cytotoxic to some human cancerous cell lines. in this study, cytotoxicity of fruit and leaf extracts as well as the latex of ficus carica l. on hela cell line were evaluated. ethanolic extracts of leaves and fruits were prepared through percolation and ethyl acetate and dichloromethane extracts were prepared by reflu...

background and objective: in addition to the use of chemicals in food, pharmaceutical, cosmetic and hygiene industries, use of herbal and natural compounds have also increased. it seems natural ingredients compared with the chemical components show less side effects, such as mutagenicity and carcinogenesis however, their use can also be associated with side effects and toxicity. some significan...