Autoimmune hemolytic anemia (AIHA) is caused by hemolysis induced by the reaction of autoantibodies with red blood cells (RBCs) [1-4]. Events that lead to AIHA include extravascular hemolysis caused by phagocytosis of erythrocyte-bound IgG in the spleen (hemolytic mechanism), activation of polyclonal B cells, reactions induced by molecular mimicry of exogenous antigens, breakdown of immune tole...

1. Hemolytic streptococcus has been found in 100 per cent of the throats of patients with scarlet fever during the 1st week of the disease. 2. The average length of time that these organisms are present in the throat varies from 10 to 20 days. 3. No morphological or cultural characteristics peculiar to the hemolytic streptococcus from scarlet fever can be demonstrated. 4. Ten immune sera have b...

Ceftriaxone-induced hemolytic anemia is a rare and often fatal phenomenon. We report here the case of a 6-year-old female with sickle cell disease who survived a brisk and profound hemolytic reaction, resulting in hemoglobin of 0.4 g/dL, after ceftriaxone infusion. Ongoing hemolysis was abrogated with aggressive supportive care, but the patient suffered extensive neurologic sequelae as a result...

We induced reverse passive Arthus (RPA) reactions in the skin of rodents and found that the contribution of complement to immune complex-mediated inflammation is species specific. Complement was found to be necessary in rats and guinea pigs but not in C57BL/6J mice. In rats, within 4 h after initiation of an RPA reaction, serum alternative pathway hemolytic titers decreased significantly below ...

Using the complement fixation reaction with whole bacterial solutions as antigens, it has been possible to confirm the existence, within the non-hemolytic streptococcus family, of two great groups. One of these groups, that which may be designated as of the left side, is related in an orderly way to the hemolytic streptococci; the other of the right side, is similarly related to the entire pneu...

An attempt has been made to interpret on the lines of the Arthus phenomenon the secondary reaction which follows the intradermal inoculation of certain non-hemolytic streptococci into rabbits; but evidence in support of this interpretation of the reaction has not been obtained. The facts make it seem probable that if this secondary reaction is due to a hypersensitive state it must be one more c...

BACKGROUND Naturally occurring alloantibodies produced against A and B red cell antigens in cats can cause acute hemolytic transfusion reactions. Blood incompatibilities, unrelated to the AB blood group system, have also been suspected after blood transfusions through routine crossmatch testing or as a result of hemolytic transfusion reactions. HYPOTHESIS Incompatible crossmatch results among...

Knull phenotype completely lacks all Kell system antigens. Anti-Ku antibody is seen in immunized persons with Knull phenotype by transfusion or pregnancy. It can cause a fatal hemolytic transfusion reaction. A 66-yr-old male patient with liver cirrhosis visited emergency center due to acute bleeding. The patient was at hypovolemic shock status: his blood pressure was 80/50 mmHg, pulse rate was ...