life-long red blood transfusion remains the main treatment for severe thalassemia. the development of hemolytic alloantibodies and erythrocyte autoantibodies complicated transfusion therapy in thalassemia patients. the frequency causes and prevention of this phenomenon among 80 transfused thalassemia patients were evaluated in ali asghar children's hospital during 1998-2004 in a cross-sectional...

The kinetics of the hemolytic reaction effected by the hemolysin of Clostridium septicum, strain 44, has been studied with regard to the effect of concentration, temperature, and hydrogen ion concentration on the rate of the hemolytic reaction. The kinetics of hemolysis was found to resemble in several respects that of enzyme-catalyzed reactions, but differed in the absence of a clearly defined...

Synonyms and related keywords: blood transfusions, blood products, acute hemolytic transfusion reactions, transfusion complications, blood product reactions, allergic transfusion reaction, blood type, circulatory volume overload, anaphylactic transfusion reaction, blood anaphylaxis, hemolytic reactions, allergic reactions, anaphylactic reaction, anaphylaxis, transfusion-related acute lung injur...

T HE ERYTHROCYTES of patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) hemolyse at 37 C. in normal compatible human sera in the absence of demonstrable antibody. The reaction is complement dependent and in vivo causes a hemolytic anemia of varying severity. The diagnostic acid hemolysis test for this disorder is performed by demonstrating hemolysis of suspect erythrocytes in the patient’s...

2. A patient who was admitted to the intensive care unit for a major gastrointestinal bleed receives a red cell transfusion. One hour after the transfusion, he complains of severe dyspnea. Over the next 30 minutes he develops respiratory failure and fevers with a chest x-ray showing infiltrates. He is intubated, but over the next 24 hours he improves and is extubated in 48 hours. What reaction ...