PURPOSE Serotonin is a well-known neurotransmitter and vasoactive substance. Recent research indicates that serotonin contributes to liver regeneration and promotes tumor growth of human hepatocellular cancer. The aim of this study is to investigate the expression of serotonin receptors in hepatocellular cancer and analyze their potential as a cytotoxic target. EXPERIMENTAL DESIGN Using a tis...

Hepatocellular carcinoma (HCC) is the most common form of liver cancer (~80%), and it is one of the few cancer types with rising incidence in the United States. This highly invasive cancer is very difficult to detect until its later stages, resulting in limited treatment options and low survival rates. There is a dearth of knowledge regarding the mechanisms associated with the effects of biomec...

Background and purpose: The aim of this study was to bioinformatically and experimentally evaluate the effect of melatonin on the expression levels of UBE2W and SSX2IP genes in melatonin treated Human Hepatocellular carcinoma G2 (HepG2) cancer cell line. UBE2W encodes a protein that promotes ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DN...

conclusions our results suggest that h. parva and h. oculata may be promising therapeutic candidates for the treatment of hcc, following further confirmatory in vivo experiments and clinical trials. results our results showed that h. parva methanolic extracts (250, 500, and 1000 µg/ml) and h. oculata methanolic extracts (200, 400, and 800 µg/ml) increased reactive oxygen species (ros) formation...

Purpose: Serotonin is a well-known neurotransmitter and vasoactive substance. Recent research indicates that serotonin contributes to liver regeneration and promotes tumor growth of human hepatocellular cancer. The aim of this study is to investigate the expression of serotonin receptors in hepatocellular cancer and analyze their potential as a cytotoxic target. Experimental Design: Using a tis...

Abstract Major hepatobiliary cancers include hepatocellular carcinoma, gallbladder and cholangiocarcinoma. There are multiple guidelines recommendations for the imaging evaluation of these cancers. This article reviews summarizes principles in The cross-sectional protocol is similar among lesions discussed at first followed by separate discussion each cancer.

Hepatocellular carcinoma (HCC) is a primary tumor of the liver that develops in setting chronic disease. HCC difficult to diagnosis due it requiring use multiple imaging modalities with goal detect tumors when they are less than or equal 2 cm size allow all possible treatment options be used. Herein, we discuss 69-year-old male stage IV cancer residing hospice presenting left middle finger oste...

Hepatocellular carcinoma (HCC) was the sixth most common cancer and third cause of cancer-related deaths worldwide in 2020. Liver resection transplantation remain cornerstone for patients with early-stage disease represent only option potential cure HCC. However, fewer than 10% are considered suitable surgery at time diagnosis. Locoregional therapies, defined as minimally invasive image-guided ...

Sorafenib is an anticancer drug used to treat late stage kidney and liver cancer. advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). also hepatocellular (a cancer) cannot be treated with surgery certain thyroid has spread other parts body radioactive iodine. class medications called kinase inhibitors. It works by blocking action abnormal protein signals cells mult...