Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV-1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV-1 strains in the brain and eye of 2 patients with acute retinal necrosis...

objective: evaluation of bax encoding plasmid for increasing efficacy of dna vaccine plasmid encoding gb of herpes simplex virus type 1. materials and methods: we compared three different dosages of bax encoding plasmid (pcbax) including 10, 25 and 50 μg of plasmid dna. they were co-injected ineradermally with glycoprotein b (gb) of herpes simplex virus (hsv)-1 encoded plasmid (pcgb) in c57bl/6...

We have investigated whether herpes simplex virus (HSV) contains structural polypeptides which are modified by myristic acid. We demonstrate that herpes simplex virions contain a family of myristylated proteins, Mr approximately 13,000 to 16,000. These were mapped, using HSV-1/HSV-2 intertypic recombinants, to 0.130 to 0.204 map units on the virus genome. Using anti-peptide sera, raised against...

Herpes Simplex Virus (HSV) is the most common cause of non-epidemic, acute focal central nervous system infection. HSV type 1 (HSV-1 or Human Herpes Virus-1 [HHV-1]) is commonly associated with oropharyngeal infections, keratoconjunctivitis, and infections of the central nervous system, whereas HSV type 2 (HSV-2 or HHV-2) commonly produces genital infections. Severe disseminated HSV infection m...

  Herpes simplex virus type 1 establishes a latent infection in the peripheral nervous system following primary infection. During latent infection, virus genome exhibit limited transcription, with the HSV LATs consistently detected in latency infected ganaglia. Following ocular infection viral latency develops in the trigeminal ganglia. In this study PCR has been used for detection of HSV-1 nuc...

Herpes simplex virus Type 1 (HSV-1) is a human neurotropic virus causing encephalitis, corneal blindness or several peripheral nervous system disorders. Herpes Simplex encephalitis (HSE) is the most devastating clinical syndrome with severe morbidity and mortality. Hydrocephalus associated with viral meningoencephalitis is an extremely rare entity with only few documented cases, predominantly d...

Background and Aims: Herpes simplex virus type 1 (HSV-1) belonging to herpes viridae family is a normal human pathogen with benign lesions in immunocompromised patients which creates serious problems. Acyclovir is used to treat herpetic infections. Because of developing drug-resistant strains, the use of medicinal plants and their related compounds with fewer side effects is considered for the ...

Herpes simplex virus meningoencephalitis (HSV ME) is a severe viral infection that affects the brain and surrounding tissues. It caused primarily by HSV type 1 (HSV-1) virus. This condition requires prompt recognition treatment due to its potential for significant morbidity mortality. We aim highlight importance of avoiding common diagnostic pitfalls in identifying meningoencephalitis, especial...

Herpes Simplex Virus Type 1 (HSV-1) is a member of the Herpesviridae family that causes herpetic disease in human. During the last 25-30 years, many investigations have been conducted on pathogenesis and molecular biology of this virus in several countries. In Iran HSV-1 has been isolated from patients and detected using immunological techniques. In this study, we investigated the molecular asp...