An efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages su...

Translation of homogeneous catalysis into heterogeneous catalysis is a promising solution to green and sustainable development in chemical industry. For this purpose, noble metal nanoparticles represent a new frontier in catalytic transformations. Many challenges remain for researchers to transform noble metal nanoparticles of heterogeneous catalytic active sites into ionic species of homogeneo...

Colloidal or heterogeneous nanocatalysts can improve the range and diversity of Cu(I)-catalysed click reactions and facilitate catalyst separation and reuse. Catalysis by metal nanoparticles raises the question as to whether heterogeneous catalysts may cause homogeneous catalysis through metal ion leaching, since the catalytic process could be mediated by the particle, or by metal ions released...

3,3,6,6-Tetramethyl-9-phenyl-3,4,6,7,9,10-hexahydroacridine-1,8-(2H,5H)-dione derivatives are synthesized by nano titanium dioxide as an efficient and reusable heterogeneous nano catalyst in a one pot multi component reaction. Easy preparation and separation of catalyst, simply workup procedure, clean reaction and reusability of the catalyst up to 7 times without appreciable loss of its catalyt...

in this paper, 4,4ʹ-bipyridinium dichloride  supported sba-15 (sba@bipy2+ 2cl-) was used for the synthesis of dihydropyrimidinones. the synthesized catalyst was characterized by ft-ir spectroscopy, scanning electron microscopy (sem), transmission electron microscopy (tem) and thermogravimetric analysis (tga). this nanocomposite was shown to be an efficient heterogeneous catalyst for the synthes...

The heterogeneous nuclear ribonucleoprotein A1 (hnRNP-A1) has been implicated in telomere protection and telomerase activation. Recent evidence has further demonstrated that hnRNP-A1 plays a crucial role in maintaining newly replicated telomeric 3' overhangs and facilitating the switch from replication protein A (RPA) to protection of telomeres 1 (POT1). The role of hnRNP-A1 in telomere protect...