background: previous studies have shown that preeclampsia is associated with elevated maternal serum homocysteine levels, but few studies have evaluated homocysteine levels in amniotic fluid in these patients. the purpose of this study was to compare amniotic fluid homocysteine levels in preeclamptic women, with those of normal pregnant women. methods: a cross sectional study was done on 46 pre...

background: rise in serum homocysteine level may be associated with higher prevalence of cardiovascular diseases in hypothyroidism. levothyroxine can partly diminish serum homocysteine level. folic acid participates in homocysteine metabolic cycle in the human body. the effect of concomitant administration of folic acid and levothyroxine on serum homocysteine level was evaluated in the present ...

homocysteine thiolactone was demonstrated to inhibit the growth of 10–12-day-old chicken embryo cardiac tissue explants at 7 × 10−9 −1 × 10−3 m concentrations in a dose-dependent manner. the maximal cardiotoxic effect of homocysteine thiolactone was detected at 1 × 10−3 m, which corresponds to severe hyperhomocysteinemia. the results of experiments on culturing of cardiac tissue explants in the...

Objective: This study aimed to investigate if the Homocysteine has recently been proposed as a serious predictive biomarker for Covid-19 infection severity. Method: In this case-control study, which involved 90 participants, 5 ml of venous blood specimen was reserved each participant, measure homocysteine, troponin-I, and high sensitive C-reactive protein in their blood, find there an associati...

Previous studies investigating homocysteine and vascular disease have relied on total plasma homocysteine as the sole index of homocysteine status. We examined the dynamic relationship between vascular endothelial function and concentrations of total, protein-bound oxidized, free oxidized, and reduced homocysteine to identify the homocysteine form associated with endothelial dysfunction in huma...

This research put forward a simple and rapid fluorescence probe method based on competition strategy to detect homocysteine. The host–guest interaction behavior between cucurbit[7]uril homocysteine was further studied via UV–vis spectroscopy, Fourier transform infrared molecular modeling, 1H NMR spectroscopy in aqueous solution. Under the optimal detection conditions, intensity of cucurbit[7]ur...

Purine nucleotides serve as immediate building blocks for the synthesis of RNAs and DNA, energy carriers co-substrates in activation many metabolites, regulators cellular metabolism, signaling molecules. Knowledge actual tissue-specific concentration these metabolites their rate is essential to studies focused on a metabolic rewiring pathogenesis different diseases, including carcinogenesis. Th...