Objective: To investigate the antioxidant and cytotoxic activities of sulfur-containing glycine imine derivatives MCF-7 (human breast adenocarcinoma) DLD-1 (colorectal cell lines. Methods: This study examined (25-200 µM) via DPPH, metal chelating reduction methods. Furthermore activity MCF-7, MCF-12A (normal epithelial) DLD-1, CCD-18CO colon fibroblast) were with MTT (3-(4,5-Dimethylthiazol-2-y...

Background: Poekilocerus pictus (Fabricius 1771), a painted grasshopper, sequesters cardenolides from its food plant, the Apple of Sodom or Aak, Calotropis procera (Aiton) W.T. Aiton (Family-Asclepiadaceae). In our present investigation, we were able to isolate Pseudomonas aeruginosa KRK6 intestine responsible for biotransformation cardenolides. Methods: was grown in methanolic extracts and mod...

the marine environment represents approximately half of the global biodiversity and could provide unlimited biological resources for the production of therapeutic drugs. marine seaweeds comprise few thousands of species representing a considerable part of the littoral biomass. extracts of the cystoseira indica and cystoseira merica were subjected to phytochemical and cytotoxicity evaluation. th...

Marine Streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. The cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (DMEHE) from marine derived actinomycete Streptomyces sp. VITSJK8 was investigated against mouse embryonic fi...

Abstract This review aimed to assess the antioxidant properties of safrole, myristicin, and terpineol from Myristica fragrans Houtt. Safrole exhibited high cytotoxic activities against numerous cancer cell lines also shown able suppress tumor angiogenesis. Myristicin is increase activity glutathione peroxidase (GPX), reductase (GR) or glutathione-disulfide-reductase (GSR), superoxide dismutase ...

The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation characterization catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use these motors possible treatment was also illustrated after biocompability had ...

In the present study, a set of 2-anilino-4-alkylaminoquinazoline derivatives were synthesized and tested for their antitumor activities in vitro against panel four human cancer cell lines DNA-binding affinity. Among compounds, 4c 5b with 4-substitution at phenyl ring found to have highest inhibitory effects breast adenocarcinoma (MCF-7), colon (HCT-116), hepatocellular carcinoma (HePG-2), skin ...

New 3,5-disubstituted-1,2,4-thiadiazoles were synthesized and together with a series of their analogs obtained earlier tested for cytotoxic activity to breast adenocarcinoma MCF-7 lung carcinoma A 549 cells. The selectivity action was determined in comparison etiologically noncancerous epithelial cells MCF-10A fibroblasts VA13. From five- six-fold revealed 3,4-dichlorophenyl-{3-[2-(2-morpholin-...

apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. caspases, a family of cysteine-dependent aspartate-directed proteases, play a critical role in the initiation and execution of apoptosis. in this study, cytotoxicity and apoptogenic effect of 2-phenyl 4-carboxamide derivatives were evaluated in sknmc (huma...