The placenta is vital to the health and development of fetus, serving deliver oxygen nutrients, facilitate removal waste products, provide a barrier pathogens other harmful substances present in maternal circulation. When these processes fail operate normally, they can lead complications pregnancy such as preeclampsia or fetal growth restriction. novel therapeutics for mother, requires mechanis...

These studies were performed to characterize the contribution of the uridine diphosphate glucuronosyltransferase (UGT) enzymes to the clearance of 3'-azido-3'-deoxythymidine (AZT) in vivo and to assess the regulation of UGT activity [including the disposition of the cofactor uridine diphosphate glucuronic acid (UDPGA)] in the placenta. Transport of AZT and the cofactor UDPGA across the human pl...

BACKGROUND In the human placenta, maternal and fetal bloods exchange substances through the surface of the villous trees: the fetal blood circulates in the villous trees, around which the maternal blood circulates. The blood flows directly influence fetal growth. Stem villi, the main supports of the villous tree, have contractile cells along the axes, whose contractions are expected to influenc...

The effect of human placenta! lactogen on the mainte nance and growth of precancerous mammary hyperplastic nodules was studied in ovariectomized, multiparous C3H/He female mice. In mice receiving injections of 0.5 mg of human placenta! lactogen twice daily for 19 days and on the morning of the 20th day, beginning the morning following bilateral ovariectomy, the number of nodules per mouse was s...

Genomic imprinting is the phenomenon whereby mono-allelic expression of certain genes occurs depending on their parental origin. The observation that imprinting only occurs in placental mammals has led to the suggestion that it may play a role in this form of reproduction. In the present study we have investigated the pattern of expression of the human PEG3 gene in the early to term placenta, a...