Citrus limonoids were demonstrated to possess potential biological activities in reducing the risk of certain diseases. Limonoids are present in citrus fruits in the form of aglycones and glucosides. At present, limonoid aglycones and limonoid glucosides are extracted in multiple steps using different solvents. In order to understand their potential bioactivity, it may be beneficial to isolate ...

Based on the large number experiments on solubilization of poorly watersoluble drugs, the author is of the opinion that hydrotropy is another type of cosolvency and all water soluble substances whether solids, liquids or gases have solubilizing properties. Therefore, aqueous solutions containing small quantities of several water-soluble excipients giving a concentrated solution, may act as a so...

Solubilization of poorly water-soluble drugs has been a very important issue in screening studies of new chemical entities as well as formulation research. Various techniques are employed to enhance the aqueous solubility of poorly water-soluble drugs and hydrotropic solubilisation is one of them. A hydrotrope is a compound that solubilises hydrophobic compounds in aqueous solution. The problem...

Abstract Objectives The main aim of the research was to analyze an economical and eco-friendly approach improve solubility norfloxacin. current analysis utilize hydrotropic solutions extract drugs from their dosage forms, avoiding use costlier harmful organic solvents. Materials Methods In this study, ultraviolet–visible spectrophotometer (model 1800, Shimadzu Corporation) used norfloxacin drug...

Celecoxib, a diaryl substituted pyrazole, is practically insoluble in water which precludes its use in parenteral and liquid dosage forms. This study explores the solubility enhancement of celecoxib using hydrotropy and cosolvency solubilization approaches. The equilibrium solubility studies were performed using hydrotropes piperazine, sodium citrate, and urea and cosolvents PEG 200, PEG 400, P...

The miscibility range for water sodium propionate pentanol mixtures has been determined at 298 K. The phase equilibria are compared with ‘normal’ and ‘ detergentless ’ microemulsion systems. Sodium propionate imposes a very slight salting out action (if any) on pentanol in dilute aqueous solutions. However, pentanol gains full miscibility with concentrated salt solutions. Volumetry was chosen t...

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...

The separation of 2,6 xylidine from 2,4 /2,6 xylidine mixtures in hydrotrope solutions was carried out. The aqueous solubilities of 2,4 xylidine and 2,6 -xylidine in different hydrotropic concentrations (0-3.0 mol/L) of sodium cumene sulfonate , citric acid and nicotinamide solutions at different system temperatures (303 to 333 K ) were studied. The percentage extraction of 2,6xylidine from 2,4...

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...