Highly hydrophilic counterions such as sodium or chloride are not good choices to achieve efficient hydrotropy.

In this paper we consider clusters in the ternary systems water–benzyl alcohol and ethanol, ethyl lactate or g-valerolactone as found with the help of dynamic and static light scattering experiments. These ternary mixtures are powerful solvent media and consist only of low-toxic solvents of natural origin. In a recent work we have shown that surfactantless microemulsions are formed in the water...

Hydrotropy is a well-established strategy to enhance the aqueous solubility of hydrophobic drugs, facilitating their formulation for oral and dermal delivery. However, most hydrotropes studied so far possess toxicity issues are inefficient, with large amounts being needed achieve significant increases. Inspired by recent developments in understanding mechanism hydrotropy that reveal ionic liqui...

A comprehensive investigation on the solubility and mass transfer coefficient enhancement of methyl benzoate through hydrotropy has been undertaken. The solubility and mass transfer coefficient studies were carried out using hydrotropes such as citric acid, urea and nicotinamide under a wide range of hydrotrope concentrations (0 to 3.0 mol/L) and different system temperatures (303 to 333 K). Th...

Abstract: In this review we have elaborated about number of hypothesis postulated to understand the mechanism hydrotropic agents, although majority haven’t justified solubility enhancement mechanism. Further it articles focuses upon parameters affecting solubilizing ability. Hydrotropes are extensively used in drug solubilization, extraction agents for various phytoconstituents, separation agen...