The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of Ondansetron Hydrochloride (OND) which is used for nausea and vomiting associated with cancer chemotherapy and radiotherapy. Permeation of OND was calculated ex vivo using porcine buccal membrane. Buccal films were developed by solvent-casting technique using Hydroxy Propyl Methyl Cellulose(HPMC E15) ...

The present study deals with the formulation and of oromucosal tablets Rizatriptan Benzoate (RB) using different bioahdesive polymer. Nine formulations were prepared by direct compression method. Hydroxypropyl methyl cellulose (HPMC K4M), Gum acacia Sodium Alginate used as buccal mucoadhesive Ethyl (EC) an impermeable backing layer. FTIR Studies showed no interaction drug, polymer excipients. 3...

Poor bioavailability is one of the most significant problems in delivery ocular drug system. Ophthalmic ointments, solutions and suspensions are frequently used dosage forms to treat disease, their effectiveness as a compromised by several limitations that lead poor bioavailability. In situ gel promising strategy improve drugs. The purpose this review discuss formulation characterization gel. T...

The present study involves design and characterization of floating microspheres with Nateglinide as model drug for prolongation of gastric residence time. Nateglinide Floating Microspheres were prepared by w/o/o emulsification solvent diffusion technique using rate controlling polymers ethyl cellulose and hydroxy propyl methyl cellulose. The shape and surface morphology of prepared microspheres...

In the present work, monolithic matrix transdermal systems containing tramadol HCl were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl citrate as a plasticizer. A 3 full factorial design was employed. The concentration of HPMC and ES were used as independent variables, while percentage drug release was selected...

Drugs that have a pharmacological effect similar to legal drugs such as narcotics and stimulants are available in the market and widely used. 5-methoxy-N,N-di-iso-propyl-tryptamine (5MeO-DIPT) and alpha-methyl-tryptamine (AMT) were categorized as narcotics and were specified as legal drugs in April 2005, and also 2,5-dimethoxy-4-n-propylthiophenethylamine (4C-T-7) and N-methyl-alpha-ethyl-3,4-m...

The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of Cyproheptadine Hydrochloride (CPH) which is a sedating antihistamine with antimuscarinic, serotonin-antagonist, and calcium-channel blocking action. Buccal films were made with Hydroxy propylcellulose (HPC EF) and Hydroxy Propyl Methyl Cellulose (HPMC E15) as mucoadhesive polymers. Permeation of CPH ...