The need for reliable biomarkers for distinguishing Crohn disease (CD) from ulcerative colitis (UC) is increasing. This study aimed at evaluating the diagnostic potential of anti-GP2 antibodies as a biomarker in Chinese patients with CD. In addition, a variety of autoantibodies, including anti-saccharomyces cerevisiae antibodies (ASCA), perinuclear anti-neutrophil cytoplasmic antibodies (PANCA)...

Anaphylactic reactions to immunoglobulin infusions in immunodeficient patients with undetectable IgA have been attributed in several reports to IgG or IgE anti-IgA antibodies. However, other reports have not supported an association between such antibodies and the development of severe reactions. We have reviewed the articles reporting reactions to immunoglobulin products in IgA-deficient patie...

Although severe reactions to immunoglobulin preparations have been frequently reported, IgE antibodies against IgA are usually not investigated; and occur predominantly in previously sensitized patients. The purpose is to report anaphylaxis to IGIV during initial infusion in a patient with common variable immunodeficiency with absent IgA without prior sensitization and in the absence of detecta...

background: alopecia areata (aa) is a noncicatricial (nonscarring) alopecia. the association between aa and celiac disease (cd) is debatable. several studies declare the relationship between aa and cd as measurement of celiac autoantibodies (anti‑gliadin iga and anti‑gliadin igg), but a few studies consider anti‑tissue transglutaminase iga. the aim of this study was to evaluate the frequency di...

BACKGROUND Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the fetus are not completely understood. OBJECTIVES To investigate the changes of the anti-H. py...

background: in some studies inflammatory bowel disease (ibd) and celiac disease were considered to be associated and some belive that this association may influence the prognosis of ibd. however, there is a cosiderable controversy regarding this association. therefore ,we aimed to assess the association of these two common digestive diseases and evaluate the complications of this association. m...

BACKGROUND In the diagnosis of celiac disease (CD), serum assays for anti-endomysium (EMA) and anti-transglutaminase (anti-tTG) antibodies have excellent diagnostic accuracy. However, these assays are less sensitive in young pediatric patients. Recently, a new ELISA test using deamidated gliadin peptides (DGP) as antigen has proved to be very sensitive and specific even in pediatric patients. I...

Background We aimed to investigate the frequency of celiac disease in children with β-thalassemia major (B-TM) in Shiraz, southern Iran. Materials and Methods In this study, the prevalence of celiac disease in children with B-TM was evaluated. Children with BTM were screened for celiac disease by ant-tissue transglutaminase (anti-tTG) IgA antibody, IgA level and anti-tTG IgG. A total o...