نتایج جستجو برای: improvement of psoriatic lesions
تعداد نتایج: 21189325 فیلتر نتایج به سال:
Psoriasis is a chronic inflammatory skin disease. Metabolic syndrome (MS) is a combination of central obesity, dyslipidemia, glucose intolerance, and elevated blood pressure. Many epidemiological surveys have revealed the association of psoriasis with MS. Narrowband ultraviolet radiation b (NB-UVB) is an effective and widely used treatment for psoriasis. The purpose of this study was to investi...
We investigated the effect of the potentially carcinogenic psoralen plus UVA radiation (PUVA) therapy on the expression of p53 in skin of psoriatic patients. p53 antibodies DO7 and Pab240, antibodies against PCNA and Ki67 and the avidin-biotin immunoperoxidase complex method were used in the immunohistochemical staining of biopsy samples from non-lesional and lesional skin of 23 patients who re...
The cellular events underlying the pathogenesis of psoriatic arthritis (PsA) and psoriasis have not yet been fully elucidated. Nevertheless, some clues to these conditions are beginning to emerge. In particular, a growing body of data supports the role of proinflammatory cytokines, such as tumour necrosis factor (TNF), in the pathophysiology of PsA and psoriasis. Raised levels of these cytokine...
Tumor Necrosis Factor alpha (TNF) as proinflammatory cytokine plays in the pathogenesis of many diseases an important role. In psoriasis and in psoriatic arthritis TNF is up-regulated in the skin lesion and in the synovitis. Recent trials showed that the blockade of TNF with the chimeric antibody infliximab is able to improve both, the skin lesions and the synovitis of the joints. In psoriasis ...
OBJECTIVES To evaluate the effectiveness of tumour necrosis factor (TNF) blockers in juvenile psoriatic arthritis (JPsA). METHODS The study was a prospective ongoing multicentre, observational study of all Dutch juvenile idiopathic arthritis (JIA) patients using biologicals. The response of arthritis was assessed by American College of Rheumatology (ACR) paediatric response and Wallace inacti...
Many investigators have reported proliferation of terminal cutaneous nerves and upregulation of various neuropeptides (substance P, vasoactive intestinal polypeptide, calcitonin gene-related peptide) in psoriatic lesions. Nerve growth factor promotes growth of nerves and causes upregulation of neuropeptides like substance P and calcitonin gene-related peptide. In this study we investigated the ...
Background: Psoriasis is a common chronic and relapsing skin disease with unknown etiology being observed at any age and any gender, having a 1. 5-3% prevalence rate among the general population. Psoriatic lesions consist of pruritic and scaling papules, residing on an erythematous base, which are more commonly found on the scalp, extensor surfaces, palms and soles, and the nails. The conventio...
Introduction Psoriasis is a common skin disease and provides a useful model to study the pathogenic significance of chemical mediators of inflammation both in vivo and in vitro. The histological features of this condition include increase epidermal cell proliferation and infiltration of neutrophils, macrophages and lymphocytes into the lesions. In fact, neutrophil infiltrates have been reported...
Introduction: According to previous studies, the prevalence of oral lesions in patients with psoriasis is on the rise. But precise knowledge of the prevalence among Iranian patients is not available. The aim of this study was to evaluate of oral lesions between psoriatic patients and comparing by past results. Materials and methods: Present descriptive-analytic study is done on psoriatic pat...
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