The development of allergic inflammation requires the orchestration of gene expression from the inflamed tissue and from the infiltrating immune cells. Since many of the cytokines that promote allergic inflammation signal through hematopoietin family receptors, the Signal Transducer and Activator of Transcription (STAT) family have obligate roles in pro-allergic cytokine-induced gene regulation...

BACKGROUND: Eczema is a common, chronic inflammatory skin disease characterized by itchy red rashes and scaly skin that can significantly affect the quality of life of patients. Moisturizing creams and emollients are often used to combat dryness and inflammation. The aim of this study was to demonstrate the efficacy of a topical study product in reducing the appearance and symptoms of eczema. O...

Background: In India about 40% of male and 25% female suffer from hair fall. Oil which is used for Shirobhyanga medicated with specific herb, beneficial hair, then it becomes more effective. Aim: To assess the effect Kaidarya (Murraya koenigii (L.) Sprengel) siddha Narikela taila in management Khalitya. Material Methods: Clinical study was carried out on 100 patients, 50 patients each trial gro...

It has been wondered why we can discriminate between itching and pain as different sensations. Several researchers have investigated neural mechanisms underlying their perceptual differences, and found that some C fibers and spinothalamic tract neurons had different sensitivity between itching and pain. These findings suggest that such differences in ascending pathways are partly associated wit...

introduction: henoch schonlein purpura (hsp) is a self-limited systemic disease with multiorgan involvement. while cutaneous involvement may wary, presenting as itching papules is not a common manifestation. in this report we discuss a case of hsp which was presented solely with itching papules; mistaken for scabies. case presentation: a 7 year old boy presented with itchy palpable papules with...

The itch sensation results from the excitation of primary sensory nerve endings in the skin, but the underlying molecular mechanisms are not completely understood. Liu et al. (2009) now report that some members of the Mrgpr class of G protein-coupled receptors mediate the itch caused by the antimalarial drug chloroquine.

Although remifentanil is used widely by many clinicians during general anesthesia, there are recent evidences of opioid-induced hyperalgesia as an adverse effect. This study aimed to determine if intraoperative remifentanil infusion caused increased pain during the postoperative period in patients who underwent a thyroidectomy. A total of 7511 patients aged ≥ 20 years, who underwent thyroidecto...

Electrically evoked itching has the strong potential to be used to investigate the central processing associated with itching at high temporal resolution by employing magnetoencephalography, electroencephalography (EEG), and event-related functional magnetic resonance imaging. However, it has not been investigated whether time-locked brain activity can be measured using this stimulus, and wheth...