Background: Premenstrual syndrome is a cyclic disorder with symptoms that are severe enough to interfere some aspect of living. The debilitating reappear each cycle, the most common being generalized headache, breast swelling and tenderness, bloating, fatigue, depression irritability. Aim: To determine efficacy mefenamic acid in treatment premenstrual women reproductive age groups. Methods: A q...

The objective of this double-blind, placebo-controlled study was to evaluate the effect of mefenamic acid and placebo on controlling irregular uterine bleeding in depot-medroxyprogesterone acetate (DMPA) users. A total of 48 DMPA users attending the Family Planning Clinic, Chulalongkorn Hospital were studied, all had abnormal bleeding. These participants were randomly divided into two groups. A...

This work investigates the potential of magnetic Fe3O4 nanoparticles as an adsorbent for separation and preconcentration of trace amounts of mefenamic acid in aquatic and biological samples, prior to spectrophotometric determination. The magnetic iron oxide nanoparticles (MIONs) were synthesized by mixing of ferrous and ferric chlorides. The possible parameters affecting the enrichment were opt...

Dr. Noritomo Itami, Hokkaido University School of Medicine, Department of Pediatrics, North 15 West 7, Kita-ku, Sapporo 060 (Japan) Dear Sir, We read the paper by Boletis et al. [1] with interest, we would like to add a similar case and suspect that mefenamic acid may promote the progression to interstitial fibrosis in some cases. A 13-year-old boy was given mefenamic acid (500 mg/day for 1 wee...

Mefenamic acid is a common widely prescribed drug with analgesic activity. Authors report two cases of multifocal fixed drug eruption induced by mefenamic acid. Cases were diagnosed on basis of clinical examination and histopathology of skin lesion. Only a few cases have been reported in the literature and these are the first two described in Greece.

Liquid chromatographic method was developed for simultaneous quantitative determination of dicyclomine hydrochloride, mefenamic acid and paracetamol in their combined dosage form. The separation was achieved using a C18 column (250×4.6 mm id, 5 μm) using acetonitrile:20 mM potassium dihydrogen phosphate 70:30 (v/v) adjusted to pH 4 using orthophosphoric acid as mobile phase at a flow rate of 1 ...

The effect of prostaglandin (PG) inhibitors differing in their chemical nature, viz. Aspirin (acetylsalicylic acid), Mefenamic acid (fenamates), Diclofenac (phenylacetic acid derivative) and Piroxicam (oxicam derivative) on the adrenal hormones was studied in acutely stressed pigeons. None of these PG blockers exerted any significant effect on the catecholamine and corticosterone content of the...

OBJECTIVES Dysmenorrhea is a common gynecologic disorder. Although non-steroidal anti-inflammatory drugs are commonly used, due to their side effects and lack of response in some individuals, other approaches such as exercise have been considered. This study compared the effect of stretching exercises and mefenamic acid on the reduction of pain and menstruation characteristics in primary dysmen...