By reviewing the literature on development of English language teaching methods in last three decades, it is obvious that idea using first (L1) second (L2) classroom has always been controversial. The history pedagogy and role foreign learning generate debates as a language. growing every day Iran, result, need for informing best policy getting more urgent. principal intent current study, inves...

This study is an attempt to provide insights into the extent of first language (L1) use while reading second language (L2) texts in a collaborative situation among tertiary ESL learners. Through the identification of reading strategies utilized by the subjects, the study is also aimed at discovering possible reasons for the use of L1 while comprehending L2 texts. Four students, whose L1 was Bah...

this study aimed to examine cross-cultural differences in performing refusal of requests between persian native speakers (pnss) and english native speakers (enss) in terms of the frequency of the semantic formulas. also examined in this study was whether persian efl learners would transfer their l1 refusal patterns into the l2, and if there would be a relation between their proficiency level an...

BACKGROUND A high-quality programmed cell-death ligand 1 (PD-L1) diagnostic assay may help predict which patients are more likely to respond to anti-programmed cell death-1 (PD-1)/PD-L1 antibody-based cancer therapy. Here we describe a PD-L1 immunohistochemical (IHC) staining protocol developed by Ventana Medical Systems Inc. and key analytical parameters of its use in formalin-fixed, paraffin-...

  Objective(s): To investigate the expression of human papilloma virus (HPV) L1 capsid protein, and human telomerase RNA component (hTERC) in cervical cancer and the role of detection of both genes in screening of cervical cancer.   Materials and Methods: A total of 309 patients were recruited and cervical exfoliated cells were collected. Immunocytochemistry was employed to detect HPV L1 capsid...

L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis. It is feasible that L1-dependent signalling contributes to these effects. However, little is known about its mechanism in tumour cells. We reported previously that L1 is cleaved...

Background: L1 retrotransposons are the most active mobile DNA elements in human genome. Unregulated L1 retrotransposition may have deleterious effect by disrupting vital genes and inducing genomic instabilities. Therefore, human cells control L1 elements by silencing their activities through epigenetic mechanisms. It has been shown that cell division and heavy metals stimulate the frequency of...

How does interaction affect categorization, and how might this vary between native and non-native speakers? When people use shared labels to categorize objects, they categorize more similarly to each other. We investigated whether interaction leads non-native speakers to categorize in the same way as native speakers. In six rounds, L1-English and L2-English/L1Mandarin speakers individually cate...