Background and Objectives: Calorie restriction (CR) is one of the proven methods of extending lifespan and slowing aging. Leptin is a nutritionally regulated adipokine that has been proposed as a possible key signal in the adaptive responses relevant to CR. Under CR, plasma leptin levels decrease, thus it was hypothesized that leptin administration may counteract CR-induced weight loss. Therefo...

results there was a significant increase (p < 0.05) in leptin levels on day 14 (12.75 + 5.8 ng/ml) and day 21 (12.91 + 3.2 ng/ml) for age group 18-30 years compared to day 14 (11.60 + 3.2 ng/ml) and day 21 (11.60 + 3.2 ng/ml) for age group 31-40 years. leptin was positively correlated with fsh on day 14, with lh on day 7 and day 21; likewise, with progesterone on day 21 and day 28 and with estr...

Craniopharyngioma (CP) is a benign tumor with high rate of obesity and frequent recurrence. Moreover, the role leptin/leptin receptors axis in prognosis CP still unknown. Plasma leptin concentration mRNA expression were assessed patients CP. association between axis, weight-related outcomes, progression-free survival (PFS) explored patients. Leptin overexpressed tissue compared to normal brain ...

Background: Several studies have recently investigated the role of leptin, the polypeptide hormone secreted primarily by white adipose tissue, in the reproduction of rodents, humans, and domestic animals. Materials and Methods: To investigate the in vitro effect of leptin on buffalo semen quality in equilibrated and frozen thawed semen, five healthy buffalo bulls (5 ejaculates from each bull) w...

Leptin, an adipocyte-derived cytokine (adipokine), has plethora of physiological roles in the body, particularly onset puberty, reproduction and immune function animal. Leptin binds with leptin receptor (LEPR) activates different intracellular signaling pathways to activate downstream gene expression process execute its functions. The present mini-review focuses on our current understanding abo...

Acute phase C-reactive protein (CRP), raised in obesity and inflammation, is a main binding protein for leptin. It is assumed that CRP contributes to leptin confrontation by preventing leptin from crossing the blood-brain barrier (BBB). Here we defined how CRP cooperates with the BBB and whether it deters leptin from attainment CNS targets. CRP was constant in blood, but did not permeate the BB...

Introduction: Leptin, secreted from adipose tissue may have some correlation with coronary artery disease according to some reports in literature. The mean concentration of plasma leptin in patients with normal and abnormal myocardial perfusion imaging (MPI) and relation of leptin levels, independently to abnormality in MPI after correction for body mass index (BMI) was evaluated. Methods...

Leptin is secreted mainly by fat, which is involved in energy metabolism and reproduction. Leptin and itsreceptor (Ob-R) have been detected in human spermatozoa and testis, thus it can be concluded leptin involves in male physiology. The goal of this study was determination of the presence of leptin receptor mRNA in the ram testis, epididymis and spermatozoa by reverse transcription polymerase ...