Local anaesthesia for fibreoptic bronchoscopy should be given by a safe technique that is not unpleasant to the patient and should provide acceptable conditions for the bronchoscopist. Single injection transcricoid local anaesthesia was compared with the "spray as you go" technique in patients having day case fibreoptic bronchoscopy. Patients were randomised to receive either 100 mg lignocaine ...

We have studied the effects of three different types of calcium channel blockers (verapamil, diltiazem, and nicardipine) on local lignocaine sensory block. The standardized tail flick test was used to measure the duration and degree of lignocaine-induced conduction block in rats. After obtaining baseline tail flick latencies (mean 3.2 s), two 100-microliter doses of 0.3% lignocaine alone, a com...

Pain intensity, and blood glucose and plasma cortisol concentrations were measured following abdominal hysterectomy in 18 patients allocated randomly to receive either i.v. lignocaine 1.5 mg kg-1 plus 2 mg kg-1 h-1, or saline. The administration of lignocaine resulted in plasma concentrations between 1.5 and 2.0 micrograms ml-1 during the 2-h study period. However, the administration of lignoca...

We have examined the effect of preoperative administration of nebulized lignocaine or saline on the intraocular pressure (IOP) response to tracheal intubation in 20 adults. In the saline group, tracheal intubation was associated with a significant increase in IOP above control and preintubation values (P less than 0.01); in the lignocaine group there was no change in IOP following intubation. A...

A typical case of transient radicular irritation after spinal anaesthesia with 2% isobaric lignocaine is described. The definition and history of this syndrome and the implications of the use of pencil point needles with lignocaine for spinal anaesthesia are discussed.

OBJECTIVE To compare the anaesthetic properties of conventional intradermal 1% plain lignocaine with a topical gel preparation of adrenaline (1:2000) and cocaine (4.7%) for use in treatment of children's lacerations. METHODS Children aged 3-16 years with lacerations (not of the digits or mucous membranes) were consecutively assigned to receive either adrenaline and cocaine (AC) or lignocaine....

AIM To compare the efficacy of 15% lignocaine spray and 8% lignocaine gel as a topical anesthetic, in reducing pain, during buccal infiltration in children. MATERIALS AND METHODS Forty-two patients aged between 7 and 12 years requiring restorative procedures/extraction/pulp therapy of primary/ permanent teeth in the maxillary arch, under buccal infiltration anesthesia were selected for the st...

Peak plasma concentrations of lignocaine were recorded in 41 patients receiving topically applied lignocaine for fiberoptic bronchoscopy. Adequate anaesthesia was achieved in all patients with an average dose per unit weight of 9.3 +/- 0.5 mg/kg (SEM) giving a mean peak plasma concentration of 2.9 +/- 0.5 mg/l-1 (SEM) (+/- SEM 0.5). The plasma concentration exceeded toxic levels of 5.0 mg/l-1 i...

AIM Anal fissures are associated with hypertonia of the internal anal sphincter and pain. We evaluated the efficacy of local application of a combination of minoxidil and lignocaine in healing anal fissures. METHODS In this prospective, randomized, double-blind study, 90 patients with anal fissure were recruited. Patients received local applications of ointments containing 5% lignocaine (n=28...

Local anaesthetics are ventilatory depressants, but previous investigators have not commented on the effects on ventilatory timing. There is concern about the possible ventilatory depression caused by systemic absorption of local anaesthetics injected extradurally. We have studied ASA grade I patients anaesthetized with a propofol infusion and breathing spontaneously; they were given in random ...