We present R package LIM (Soetaert and van Oevelen 2009) which is designed for reading and solving linear inverse models (LIM). The model problem is formulated in text files in a way that is natural and comprehensible. LIM then converts this input into the required linear equality and inequality conditions, which can be solved either by least squares or by linear programming techniques. By lett...

Latency Insertion Method (LIM) can be applied to divide a large system model into a multiplicity of smaller models to reduce simulation execution time. In this paper we have developed an algorithm for optimal placement of LIM connectors into a large system model so that the large model can be partitioned into many smaller models to achieve maximum speed up. Testing results showed that for refer...

LIM transcription factors bind to nuclear LIM interactor (Ldb/NLI/Clim) in specific ratios to form higher-order complexes that regulate gene expression. Here we examined how the dosage of LIM homeodomain proteins Isl1 and Isl2 and LIM-only protein Lmo4 influences the assembly and function of complexes involved in the generation of spinal motor neurons (MNs) and V2a interneurons (INs). Reducing ...

The PDZ and LIM domain-containing protein family is encoded by a diverse group of genes whose phylogeny has currently not been analyzed. In mammals, ten genes are found that encode both a PDZ- and one or several LIM-domains. These genes are: ALP, RIL, Elfin (CLP36), Mystique, Enigma (LMP-1), Enigma homologue (ENH), ZASP (Cypher, Oracle), LMO7 and the two LIM domain kinases (LIMK1 and LIMK2). As...

We discuss a novel approach to the mathematical analysis of equations with memory, based on the notion of a state. This is the initial configuration of the system at time t = 0 which can be unambiguously determined by the knowledge of the dynamics for positive times. As a model, for a nonincreasing convex function G : R → R such that G(0) = lim s→0 G(s) > lim s→∞ G(s) > 0 we consider an abstrac...

LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. The four LMO and 12 LIM-HD proteins in mammals are expressed in a combinatorial manner in many cell types, forming a transcriptional 'LIM code'. The proteins all contain a pair of close...

LIM domains are found in a variety of proteins, including cytoplasmic and nuclear LIM-only proteins, LIM-homeodomain (LIM-HD) transcription factors and LIM-kinases. Although the ability of LIM domains to interact with other proteins has been clearly established in vitro and in cultured cells, their in vivo function is unknown. Here we use Drosophila to test the roles of the LIM domains of the L...