BACKGROUND The cornea is responsible for two-thirds of the eye's refractive power which is a function of the shape and refractive index. The aim of this present study is to examine human eyes in vivo for corneal shape changes in response to short-term elevation in intraocular pressure. METHODS Videokeratographic and tonometric assessments at baseline were compared with the same assessments wh...

A candidate for refractive surgery presented with classic (type I) Ehlers-Danlos syndrome (EDS). Clinical examination revealed blue sclera, limbus-to-limbus corneal thinning, myopia, and astigmatism. Orbscan (Bausch & Lomb) pachymetry mapping provided a striking demonstration of the limbus-to-limbus thinning with a central corneal thickness of 360 microm in the right eye and 383 microm in the l...

The Purpose of present study was to investigate the effect of riboflavin/ultraviolet-A-induced collagen cross-linking (CXL) on central cornea, limbus and intraocular pressure (IOP). This was an animal experimental study. The right corneas of 10 rabbits were ultraviolet-A irradiated (3 mW/cm2 for 30 minutes) after de-epithelialization and instillation of 0.1% riboflavin / 20% Dextran drops. Left...

The development of the cornea, a highly specialized transparent tissue located at the anterior of the eye, is coordinated by a variety of molecules and cells. Here, we report that mast cells (MCs), recently found to be involved in morphogenesis, played a potentially important role in corneal development in mice. We show that two different waves of MC migration occurred during corneal developmen...

PURPOSE To investigate the expression and role of the Wnt signaling pathway in human limbal stem cells (LSCs). METHODS Total RNA was isolated from the human limbus and central cornea. Limbal or cornea-specific transcripts were identified through quantitative real-time PCR. Protein expression of Wnt molecules was confirmed by immunohistochemistry on human ocular tissue. Activation of Wnt signa...

PURPOSE Aspects of the biomechanics and surface topography of fellow human corneas are known to exhibit midline symmetry, but the structural basis of these observations is poorly understood. The mechanical performance of the cornea is strongly influenced by the organization of stromal collagen fibrils. The present study was designed to examine and compare the organization of collagen fibrils in...

It has been noted that patients suffering from long-standing rheumatoid arthritis often display a characteristic corneal lesion. This consists of a partial opacity of the periphery of the cornea involving part or all of its circumference. The cornea in this area is thinned, usually by about a third of its normal thickness and has a well-demarcated central edge. It is minimally vascularized by s...

The cornea is the main refracting lens in the eye. As part of the outer tunic it has to be resilient, a property conferred by the organisation of the constituent collagen. It also has to be sufficiently elastic to regain its exact shape when deformed, in order not to distort the retinal image. The basis of this elasticity is not fully understood. The purpose of this study was to characterise in...

The homeostasis of the epidermis and corneal epithelium is maintained by proliferation differentiation their corresponding stem cells, keratinocytes in basal layer epidermis, limbal cells limbus cornea. Keratinocytes are morphologically similar but distinct fates to support organ-specific functions. A potential disease mechanism underlying opacity acquiring cell non-transparent emphasizing impo...